Food Additives & Ingredients Supplier – Newseed Chemical Co., Limited

Sodium Saccharin E954

Sodium Saccharin is the first generation artificial sweetener, it is used widely in toothpaste than in food. This article share more information for this sweetener.

Saccharin and Sodium Saccharin E954

Saccharin

Saccharin is not the same with Sodium Saccharin. Another name of it is insoluble Saccharin, it is mainly used to produce Sodium Saccharin. The chemical formula as follows:

Chemical Name: O-Benzoic Sulfimide
Molecular formula:C7H5N03S
Molecular Weight: 183.19

Sodium Saccharin E954

E954 is the sodium salt of Saccharin. It is the first generation of artificial sweetener, its sweet degree is about 500 times than that of sugar. It is widely used in toothpaste, mouth wave, drinks, medicines, feed, electricity plating and etc. It’s harmless to the human body and it’s can not be absorbed by the body as it can be discharged completely through body metabolism.

It has two Specifications in the market, Dehydrate (with 15% water, CAS number 6155-57-3) and Anhydrous(with 6% water, CAS number 128-44-9).

Dehydrate

Dehydrate is with 15% water. It has 4-6 mesh,5-8 mesh,6-10mesh, 8-12mesh,8-16mesh,10-20mesh,20-40 mesh and 40-80 mesh in the market.

Chemical Name: Sodium O-Benzoic Sulfimide
Molecular formula: C7H4N03SNa2H20
Molecular Weight: 241.20

CAS number 6155-57-3

Anhydrous

Another name of Anhydrous is Spray-dried with 6% water. It has 100mesh in the market.
Chemical Name: Sodium O-Benzoic Sulfimide
Molecular formula:C7H4N03SNa
Molecular Weight: 205.17

CAS number 128-44-9

Application & Use

In low-calorie and sugar-free food & beverage

Research also has shown that health professionals believe it is especially beneficial to obese individuals and persons with diabetes. Additionally, research indicates that E954 may help to reduce the risk of dental caries. It continues to be important for a wide range of low-calorie and sugar-free food & beverage applications.

It is used in such products as soft drinks, tabletop sweeteners, baked goods, jams, chewing gum, canned fruit, candy, dessert toppings, and salad dressings. Additionally, personal care products such as toothpaste, mouthwash, hygiene/cosmetic products, vitamins, and pharmaceuticals contain E954.

Sweeteners blends

The current availability of E954 and other low-calorie sweeteners, such as aspartame, acesulfame potassium, neotame, and sucralose, allows manufacturers to utilize a “multiple sweetener approach” — using the most appropriate sweetener, or combination of sweeteners, for a given product. Blending a variety of low-calorie sweeteners provides products with increased stability, improved taste, lower production costs, and more choices for the consumer.

Additionally, blending E954 with one or more low calorie sweeteners can result in sweetness synergy (the resulting sweetness is greater than the sum of the sweetness of the individual sweeteners), which can decrease the total amount of sweetener.

Sodium Saccharin E954 is stable when heated, even in the presence of acids, does not react chemically with other food ingredients, and stores well. In its acidic form, Saccharin is not particularly water-soluble. The form used as an artificial sweetener is usually its sodium salt. People restricting their dietary sodium intake sometimes use calcium salt, Calcium Saccharin.

In toothpaste?

It is a sugar substitute for toothpaste, mouthwash, beverages, table-top sweeteners, confectionery, electro-plating and etc. From our observing, there is lot of toothpaste that contains E954. The use quantity in toothpaste is more than 50% of its total consumption in the market.

It does not promote tooth decay in toothpaste while sugar can. Toothpaste must have thickeners to stay on the toothbrush and squeeze out of the tube. It must have detergents to remove fatty films, and water softeners to make the detergents work better, and sweeteners, preferably non-nutritive, so bacteria are not encouraged.

In the feed?

It is intended to be used as a sweetener in feed and water for drinking for piglets, pigs for fattening and veal calves. The Panel on Additives and Products or Substances used in Animal Feed(FEEDAP) considers the proposed maximum use level of 150 mg/kg feed as safe for calves and pigs for fattening.

For piglets (sucking and weaned piglets), a lower level of 100 mg/kg complete feed is considered safe. The corresponding maximum safe concentrations in water for drinking are 30 mg/L for piglets and 50 mg/L for pigs for fattening, respectively.

Source: Safety and efficacy of sodium saccharin when used as a feed flavor for piglets, pigs for fattening, calves for rearing and calves for fattening

Benefits

Zero glycemic index and beneficial to diabetes

It may be useful for people with diabetes. Saccharin produces no glycemic response and may help control caloric intake. E954 is both calorie and carbohydrate free. It is appropriate to use it for medical and nutrition therapy (MNT) for people with diabetes, and dietetic professionals may incorporate saccharin into the individualized meal plans of their patients who have diabetes.

Zero calories

Meanwhile, it produces zero calories and is useful for people trying to control their weight. It may assist in weight management, control of blood glucose and prevention of dental caries. Replacing full-calorie products with it may help promote modest weight loss and may facilitate long-term maintenance of weight loss.

It has a long history (more than 100 years) of safe use and contributes no calories to the diet because the human body cannot metabolize it. (It is excreted in the same form it is ingested.)

Tooth health

Does not contribute to tooth decay. It is also inexpensive when compared with the second generation artificial sweeteners (aspartame and acesulfame k) and the third generation artificial sweeteners (sucralose).

Heat Stable

It is 500 times sweeter than sucrose. It has the ability to synergize the sweetening power of both nutritive and nonnutritive sweeteners, and its sweetening power is stable with heating. These factors make it an excellent food additive in manufactured products. During such blending of sweeteners, it can provide stability to maintain the product’s sweetness over a prolonged period of time. It also has a long shelf life.

As a tabletop sweetener, E954 is available in granular form (mostly 20-40 mesh and 40-80 mesh).

It is useful for consumers who want to create lower-calorie, lower-sugar versions of their favorite recipes. Because it is heat stable it is a good choice for use in cooking, baking, and canning/preserving. Depending on the type of recipe, e951 may be used to replace 50-100 percent of the sugar without sacrificing taste or other aspects of palatability.

Source: saccharin.org

Safety

It has been the subject of extensive scientific research. It is one of the most studied ingredients in the food supply. Although the totality of the available research indicates it is safe for human consumption, there has been controversy over its safety.

The basis for the controversy rests primarily on findings of bladder tumors in some male rats fed with high doses. Considerable research, however, indicates safety at human levels of consumption.

In addition, the level of human consumption of is very small compared to the levels used in rat studies. Further, although past research found an increased risk of bladder tumors in male rats ingesting with high amounts, additional research has discovered that the mechanism by which the tumors developed was specific to male rats and does not apply in humans.

The average user ingests less than one ounce of the sweetener each year. The following scientific data demonstrates its safety:

Extensive research on human populations has established no association between sodium saccharin and cancer. More than 30 human studies indicated it is safety at human levels of consumption. These studies include multiple generations of users.

In 14 single-generation animal studies involving several species of animals, it did not induce cancer in any organ, even at exceptionally high dose levels.

The body does not metabolize it and does not react with DNA (nucleic acid present in all living cells).

E954 is approved in more than 100 countries around the world and has been determined to be safe by regulatory agencies around the world, including the U.S. Food and Drug Administration (FDA), Health Canada, the European Food Safety Authority (EFSA) and the Joint Expert Committee on Food Additives (JECFA) of the World Health Organization (WHO).

In summary, research conducted over the past 25 years and a history of human use of over 100 years overwhelmingly demonstrate that it does not cause cancer in humans.

Safety supported

1993 – World Health Organization (WHO) Confirmed as a safe artificial sweetener for human consumption

1998 – International Agency for Research on cancer (iARc) Deleted from list of carcinogen

2000 – National Toxicology Program (nTP) Deleted from list of carcinogens

2001 – Food and Drug Administration (FDA) Declared safe for human consumption

2010 – Environmental Protection Agency (ePA) Deleted from list of toxic materials

2011 – The Wall street Journal (WsJ) Us President Barack Obama commented that the ePA’s decision to eliminate the regulation on saccharin was wise.

Side Effects

Discovered in 1879 and 500 times sweeter than table sugar, It is added to some foods to reduce the calorie count without stripping the food of its sweet flavor. Though there is some controversy about the use of artificial sweeteners and health, it is recognized as safe by the U.S. Food and Drug Administration.

Certain diet and low-calorie foods contain saccharin, and they include the artificial sweetener in the ingredient list.

It is approved for use in food as a non-nutritive sweetener. It is 500times sweeter than table sugar (sucrose), and it does not contain any calories.

First discovered and used in 1879, sodium saccharin is currently approved for use, under certain conditions, in beverages, fruit juice drinks, and bases or mixes when prepared for consumption in accordance with directions, as a sugar substitute for cooking or table use, and in processed foods. It is also approved for use for certain technological purposes.

In the early 1970s, it was linked with the development of bladder cancer in laboratory rats, which led Congress to mandate additional studies and the presence of a warning label on saccharin-containing products until such warning could be shown to be unnecessary. Since then, more than 30 human studies demonstrated that the results found in rats were not relevant to humans, and that it is safe for human consumption.

In 2000, the National Toxicology Program of the National Institutes of Health concluded that it should be removed from the list of potential carcinogens. Products containing saccharin no longer have to carry the warning label.

Source: Additional Information about High-Intensity Sweeteners Permitted for Use in Food in the United States.

Sodium Saccharin VS Aspartame

Its strength over aspartame is not only limited to its economic value. It can also be preserved for a long period of time without decomposition and can also act as an effective stabilizer. Moreover, it is thermal resistant. In an experiment, E954 and Aspartame E951 were heated for 30 minutes.

In the final results, E954 did not show any change in its composition, regardless of temperature. On the other hand, aspartame started to decompose at 150°C, became 91% decomposed at 170°C, and decomposed completely after 180°C. The final results appear that aspartame is not appropriate as a sweetener for high temperature usage in food such as baked goods.

Thermal resistance Comparison Between E954 and E951

Decomposition Rate According to Temperature

Market Trend

Sodium Saccharin is one of the oldest artificial, non-nutritive sweeteners. It has no caloric value and our body does not metabolize it and excrete unchanged. It is also better for oral health (such as toothpaste, mouth wave) as compared to table sugar since it does not promote tooth decay.

We can easily find it in the food and beverage industry in diet carbonated drinks and other low-calorie products. According to the latest report by IMARC Group, titled “Saccharin Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2018-2023”, the global saccharin market reached a value of US$ 260 Million in 2017. The market is further expected to reach a value of US$ 339 Million by 2023, growing at a CAGR of 6% during 2018-2023.

The rising health consciousness among the consumers regarding the negative effects of sugar consumption has led to an increase in the demand for artificial sweeteners. Since it is cheaper as compared to most other artificial sweeteners (aspartame, acesulfame k, sucralose), it is used extensively in its end-use sectors. The use is also important for people who require a diet with the restriction on caloric or carbohydrate intake, such as diabetics.

Source: Saccharin Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2018-2023

With the popularity of plant-based sweeteners and other artificial sweeteners, we think the use may decrease especially in food and drink application, can the market keep go up? It’s hard to say.

Manufacturers

The capacity from China manufacturers takes a large number of global sodium saccharin market share, the manufacturers like Keifeng, Tianjin North Food (TNF), Changjie and Shanghai Fortune who are in the market for years, China manufacturers export Dehydrate (with 15% water, CAS number 6155-57-3) 20-40mesh and 40-80mesh much, other mesh sizes like 4-6 mesh,5-8 mesh,6-10mesh, 8-12mesh,8-16mesh,10-20mesh are little; also with Anhydrous(with 6% water, CAS number 128-44-9). There is also a manufacturer in Korea, named JMC.

Shanghai Fortune won the antidumping case for USA market so it had more advantages than other China manufacturers. Shanghai Fortune together with JMC take over more than 80% market share in USA during the antidumping.

Manufacturing process

The manufacturing process is from chemical synthesis. The raw materials used as follows: Phthalic Anhydride, Ammoonia, Sodium Hydroxide, Methyl Alcohol, Sodium Hydroxide, Hydrochloric Acid, Sodium Nitrite, Copper Sulphate, Sulphur Dioxide, Toluene, Liquid Chlorine, Ammonia, Sodium Bicarbonate, Potassium Permanganate, Sodium Pyrosulfite.

Posted on 14 Sep 2018
By Marketing
In Blog Article

Vitamin C (L-Ascorbic acid)

Nowadays, you can see vitamin c everywhere, especially in the drug store. The article here is to better understand this product.

What Is L-Ascorbic Acid?

L-Ascorbic acid is an antioxidant, also known as Vitamin C (VC), naturally found in food and used as a vitamin supplement.

It is used as an antioxidant in food. It is necessary to form collagen, an important protein used to make skin, scar tissue, tendons, ligaments, and blood vessels. It is also essential for the healing of wounds, and for the repair and maintenance of cartilage, bones, and teeth.

Chemical Structure

Its chemical structure is similar to glucose and is a polyhydroxy compound. Its two adjacent enol-type hydroxyl groups on the 2nd and 3rd positions in the molecule are easily dissociated to release H+, so it has the property of acid.

Food Sources

The main food source of Vitamin C (L-Ascorbic acid) is from fresh vegetables and fruits. The high source in vegetables like pepper, garland chrysanthemum, bitter gourd, beans, spinach, potatoes, leeks, etc. And The fruits like jujube, fresh dates, strawberries, citrus, lemon and so on are high with VC.

D and L Types

Ascorbic acid has two forms, L-type and D-type, but the latter has no biological activity.

L-Ascorbic acid

We call Vitamin C in the market is usually the L form. L type can be derived from both natural (fruits and vegetables) and synthetic manufacturing process. It is commonly produced synthetically which is sold as the raw materials in the market.

D-Ascorbic acid

Although the chemical properties of D-ascorbic acid is same with L-ascorbic acid, it shares a different structure, that makes it impossible for D-ascorbic acid to be synthesized by your body and cannot be used as a vitamin supplement. Thus, it has no biological activity.

Property

It is a colorless, odorless crystal powder that is easily soluble in water and insoluble in organic solvents. Stable in acidic condition, but will be oxidized under the condition of oxygen, heat, light and alkaline substances in the air.

Manufacturing process

The manufacturing process of VC is from fermentation, two microbial are used, The ‘Black acetic acid bacteria’ is used in the 1st step fermentation. ‘Bacillus megaterium’ and ‘Gluconobacter oxydans’ are used in the 2nd step fermentation. Totally 24 processes are needed to get the finished product- Vitamin C.

Below is the brief flow chart and you’ll see how is L- ascorbic acid made and where does it come from fermentation and chemical synthesis.

What Are Health Benefits To Our Body?

The benefits including:

form antibodies and collagen
the repairment of tissue (including some redox)
the metabolism of phenylalanine, tyrosine and folic acid
the utilization of iron and carbohydrates
the synthesis of fat and protein
the maintenance of immune function, hydroxyl and serotonin
maintain the integrity of the blood vessels
promote the absorption of non-heme iron and other necessary

Also, it has the benefits of anti-oxidation, anti-free radicals can inhibit the formation of tyrosinase, so as to achieve whitening, blemish effect.

In humans, VC is a highly effective antioxidant that is used to reduce the oxidative stress of ascorbate peroxidase substrates. There are many important biosynthetic processes that also require it to participate.

What Are Uses In Our Daily Life?

Food

It can be used as nutritional supplements, Antioxidants, Color protection agents in food. As Vitamin C (L-Ascorbic acid) is not sour and soluble in water, it is easy to use. Ascorbic acid is generally used for jams, canned fruits, transparent hard candies, fruit juices and etc. Sodium Ascorbate is used in ham, sausages, fish cakes to fix the flesh color and keep it fresh. If ascorbic acid is used, the pH will decrease and the water retention will be affected. It has the effects of preventing oxidation and stabilizing the color of chilled aquatic products.

Feed

It can be used in feed additives. Not like Vitamin B series, which used widely in feed than food, Vitamin C is used much in food than feed.

Cosmetic

Its salts are used in a variety of cosmetics and personal care products including makeup, as well as skin and hair care products as antioxidants to slow deterioration caused by exposure to the air and also to control the PH of the finished product.

What Are The Possible Side effects?

Allergy symptoms

Seldom people are allergic to Ascorbic acid. When taking a vitamin C supplement or a beverage that contains ascorbic acid, such as fortified juices, the allergy symptoms may include asthma, headaches, itching, fatigue, skin rashes, runny nose, sniffling, wheezing and congestion. Common skin allergy symptoms include hives, eczema and general skin itching.

Market

Market demand will increase

Global Vitamin C (L-Ascorbic acid) market is expected to witness growth over the forecast period owing to increasing demand from industries including food & beverage, pharmaceuticals, chemicals, personal care and cosmetics.

In addition, growing demand for potassium, calcium and sodium salts of ascorbic acid as an antioxidant food additive is expected to drive the market over the next six years. Uncertain raw material supply and resulting price fluctuations are anticipated to hamper the market growth (in the 2017 market). Now the market price seems to go down to a normal level.

China is the big Vitamin c manufacturer, and almost all VC in global market is from China. Manufacturers and suppliers in China like:

DSM
CSPC Pharma
Shandong Luwei
Northeast Pharma
Ningxia Qiyuan
Zhengzhou Tuoyang

The export quantity from China has increased year by year, with 131,000 tons exported in 2016 and 148,000 tons exported in 2017. However, compared with the domestic total production capacity of 200,000 tons, the industry is still in surplus.

Since 2012, the unit price of export has remained at around 3.6 U.S. dollars per kilogram for a long period of time, resulting in a loss in the entire industry. In 2017, with the government strict control in environmental pollution and other conditions, the price of Vitamin C increased a lot even more than USD10/kg.

From January to December of 2017, China exported 148,796 tons of vitamin c, which increased by 13.4% compared with that in 2016. From January to December of 2017, the number of China’s exports was US$ 879,741,000, an increase of 104.1% than in 2016.

Posted on 23 Jun 2018
By Marketing
In Blog Article

Food and feed grade Vitamin B12 cyanocobalamin

What Is Vitamin B₁₂Cyanocobalamin?

Cyanocobalamin, also called cobalamin, is a synthetic form of Vitamin B₁₂. Cyanocobalamin is used to treat Vitamin B₁₂ deficiency in people (also in animals) with pernicious anemia and other conditions. As cyanocobalamin contains cyanide, it can not be used directly in the body and must be broken down and converted into methylcobalamin and adenosylcobalamin.

Cyanocobalamin is commonly used and found in vitamins and dietary supplements manufacturing for its lower cost among other 4 types of vitamin b12. It is not naturally occurring and can only be manufactured through chemical synthesis.

Four types of Vitamin B₁₂

There are four types of Vitamin b12: Cyanocobalamin, Hydroxocobalamin, Adenosylcobalamin and Mecobalamin. Cyanocobalamin is the only type that contains metallic elements.

Four types all have the same function – prevent and treat megaloblastic anemia & peripheral nerve diseases.

The human body can only use Methylcobalamin and Adenosylcobalamin directly, which are two active coenzyme forms of vitamin B12 in the body. Another two cobalamins must be converted into these two forms first and then can be utilized.

Let’s see the details:

1. Cyanocobalamin

It is dark red crystals or crystalline powder. It functions after converted into methylcobalamin and adenosylcobalamin in the body. Its stability is the best among the four types, as well as its absorption rate in the body is the highest.

Although it cannot be directly utilized by the human body, it has the same effect and function with adenosylcobalamin.

2. Hydroxocobalamin

It is dark red crystals or crystalline powder with better solubility in water. Sometimes it is called long-acting cobalamin due to its slow metabolism in the urine. Compared with cyanocobalamin and methylcobalamin, hydroxocobalamin can reach a higher concentration in the eye, which is beneficial to relieve visual fatigue and be nutritional to the optic nerve, so resulting in a certain effect on toxic amblyopia from tobacco.

In addition, hydroxocobalamin can rapidly combine with free cyanide in aqueous solution to form non-toxic cyanocobalamin, and it has been approved by many countries for the treatment of known or suspected cyanide poisoning.

3. Methylcobalamin

It is a bright red needle crystal or crystalline powder. Its absorption rate in the human body is second to cyanocobalamin. In comparison with the other three types, it has a better transmission of nerve tissue, which can promote the metabolism of nucleic acid-protein-lipid and can repair damaged nerve tissue.

Clinically, it has obvious curative effect on peripheral nerve diseases such as neurological disorders, multiple neuritis caused by diabetes, especially numbness, pain, and paralysis. In the treatment of peripheral neuropathy, the clinical safety and efficacy of mecobalamin are superior to adenosylcobalamin and cyanocobalamin.

4. Adenosylcobalamin

It is a yellow-orange hexagonal crystal that becomes deep red when exposed to air. Adenosylcobalamin is used internationally as a biochemical reagent and test reagent.

At present, only the Chinese Pharmacopoeia takes it as a drug. Adenosylcobalamin has been used in the Chinese market for many years and its role is basically the same as that of the other three types. It is used not only for the treatment of megaloblastic anemia, but also for malnutrition anemia, anemia during pregnancy, and leukopenia caused by radiation and chemotherapy drugs.

Adenosine cobalamin can increase hemoglobin content and improve anemia in the body.

Here let’s introduce Cyanocobalamin more.

Property

Appearance

Crimson crystals or crystalline powder with flavorless and tasteless.

Stability

The stability is not good and decomposed when exposed to light so the storage condition should be protected from light. Also, it is easy to absorb moisture in the air.

Solubility

Slightly soluble in water or ethanol. Soluble in alcohol, insoluble in acetone chloroform and ether.

Molar mass

1355.38 g/mol

Chemical Formula

C₆₃H₈₈CoN₁₄O₁₄P

Chemical Structure

What Are Food & Feed Uses Of Cyanocobalamin?

Food

It is widely used as a supplement in cereal products and certain beverages. ‘Dietetic’ foods such as slimming foods and infant formulas are often fortified with vitamins, including B12. Fortification with Vitamin B₁₂ is especially important for products aimed at people with a low dietary intake, such as vegans.

Feed Additives/Poultry

It is an indispensable micronutrient for the growth of the animals. Feed grade cyanocobalamin can promote the growth and development of poultry, especially young poultry.

The lack of Vitamin B₁₂ in non-ruminant animals such as pigs and chickens will result in the stagnation of growth and development, and a few pigs may develop mild normal red cell anemia. In addition, the hatching rate of chickens and the reproductive rate of pigs can also be reduced with the deficiency of vitamin B12. The clinical symptoms of deficiency include loss of appetite, stagnation, anemia, and severe neurological symptoms.

What Are Possible Side effects?

It is generally considered safe but possible side effects of cyanocobalamin injection include allergic reactions such as hives, difficult breathing; redness of the face; swelling of the arms, hands, feet, ankles or lower legs; extreme thirst; and diarrhea. Less-serious side effects may include headache, dizziness, leg pain, itching, or rash.

Reference: https://en.wikipedia.org/wiki/Cyanocobalamin

Two FAQs

1. Does Cyanocobalamin Contain Cyanide?

Yes, Cyanocobalamin contains cyanide, but Don’t be panic as the percentage is very little and will be excreted from the body. Our body can deal with small amounts of cyanide, usually by using sodium thiosulfate, converting the cyanide ions to thiocyanate, which will be excreted from body. Cyanocobalamin is safe and used as food additives and can be found in many health supplements.

According to the European Food Safety Authority, “Data of from a Norwegian dietary survey show that the average and high (97.5th percentile) daily intake of [cyanide] among consumers amounts to respectively 95 and 372 micrograms/person or 1.4 and 5.4 micrograms/kg bw/day.” The amount of cyanide in a 1,000 microgram cyanocobalamin is 20 micrograms. (1)

Nature Sources Of Cyanide

The safety of cyanocobalamin has raised health concerns due to cyanide. Cyanide is widely found in nature. Cassava, sorghum, corn, beans, millet, cabbage, flaxseed, bamboo, and other plants contain cyanide. Cyanide in edible plants is mostly in the form of cyanide glycosides.

There are at least more than 2,000 species of plants that contain this component, of which about 1,000 are core species. People usually eat almonds, bayberry, grape seeds, apple seeds, peaches, plums, and cherries, and their cores contain cyanide.

In addition, small amounts of hydrogen cyanide are also detected in milk, distilled spirits, and fruit and wine products sold on the market; trace amounts of cyanide are also detected in some grains and water.

2. What Is The Difference Between Methylcobalamin And Cyanocobalamin?

They’re two forms of Vitamin B12. Cyano group at the cobalt is replaced with a methyl group that makes the difference between methylcobalamin and cyanocobalamin.

Cyanocobalamin and methylcobalamin are the same compounds with only one molecule differentiating the two. Cyanocobalamin has a cyanide donor, meaning that a molecule of cyanide is attached to the cobalamin compound. Instead of cyanide, methylcobalamin has a methyl donor attached to the cobalamin compound. Though the difference is small, it can have an impact on your health.

Specification

Feed Grade

Specification: CP2010/USP35/EP6.0/BP2010

Assay: 1% 2% 5%

Packaging: 20kg/carton 25kg/drum
Carrier: Corn starch, Calcium Carbonate
Character: Pale red powder, easy to absorb moisture

When used as the feed additive for livestock and poultry nutrition, its some function as follows:

Promote the generation of livestock and poultry
Prevent pellagra, infectious dermatitis, poor fledging so that promote the growth.
Increase the rate of incubation and at the same time decrease the rate of dead embryos.

Food Grade

Specification: CP2010/USP35/EP6.0/BP2010

Assay: 1% 2% 5%

Packing: 20kg/carton 25kg/drum

Carrier: Corn starch, Mannitol, Lactose, Di-calcium Phosphate

Character: Pale red powder, easy to absorb moisture

Shelf life: 2 years

Posted on 22 Jun 2018
By Marketing
In Blog Article

How to choose best suitable Steviol glycosides for your production?

Steviol glycosides market trend

With the background of global trend of reducing sugar, major food companies’ new product sugar-reduction programs have turned to natural sweeteners which is considered has a higher safety. Mintel’s data: In 2017, the developed new products contain Steviol glycosides grew 10%; and Steviol glycosides take part of 28% in foods and beverages that used high intensity sweeteners, a little higher than another high intensity sweetener – aspartame, which takes 25%.

Food and beverages that contain Steviol glycosides as sweetener are found all over the world, and the top two regions are Asia Pacific (40%) and Europe (22%), followed by Latin America, North America, and Middle East/Africa.

The ranked number of Steviol glycosides based products in 2017 were: snacks, juice drinks, dairy products, carbonated drinks and confectionery. From 2016 to 2017, the number of Steviol glycosides based foods and beverages developed specifically for children increased by 16%. Steviol glycosides market trend is gradually increasing.

Steviol glycosides tastes misunderstanding

Stevia glycosides are FDA-GRAS approved, zero-calorie, 150 to 400 times sweeter than cane sugar. The cost of using Stevia glycosides is 30-40% of sucrose at the same level of sweet. At the same time, Stevia glycosides can meet the international natural health trends. It is a good choice for health and sugar reduction.

However, at present, there are misunderstanding of the taste and the customers evaluation of Steviol glycosides in the market is not friendly. Even if the manufacturing process and technology have been continuously upgraded and the taste has been optimized, it still does not eliminate someone’s prejudice against stevia and Steviol glycosides.

Stevia extracts mainly contain 9 Steviol glycosides: Stevioside, Rebaudioside A, Rebaudioside B, Rebaudioside C, Rebaudioside D, Rebaudioside F, Dulcoside A, Rubusoside and Steviolbioside.

Its taste is related with the structure itself, but most perhaps the undesirable taste comes from the inaccuracy of the selected specifications from customers.

Generations of Steviol glycosides

First generation TSG series: recommended TSG95/RebA60

There are many specifications of Stevia glycosides and the taste varies greatly from one specification to another. Also, its taste performance in different finished products is sometimes different even if with the same specification. Food and beverage consumers have very high taste requirements for their product, so choose a best suitable steviol glycosides for their production is very important. In order to comply with international trends and meet the taste needs, we must have a very thorough understanding of the product’s application attributes.

According to taste requirements and optimization process of raw material production and purification process, steviol glycosides has the following generations and specifications:

The First generation: Total Stevia glycosides (TSG) series, such as TSG95, TSG90, TSG85, etc.
The Second generation: high purity monoglycosides, Stevioside, RebA, RebB, RebC, RebD95, RebM, etc., mainstream application specifications are like RebA 97%, RebA 99%
The Third generation: mixed steviol glycoside, self-flavor modification scheme: RebA+RebB, RebA+RebC, RebA+RebD, RebA+RebM, etc.
The Fourth generation is Stevia glycosides derivatives: glucosyl stevioside, such as GB2760 GSG75%, FEMA 4728 TSG80%, TSG95%, etc.

The first generation, we recommended TSG95/RebA60. Steviol glycosides are mainly used in domestic markets at the specifications of TSG85 and TSG90. Steviol glycosides contain the structure of hydrophobic stearyl groups such as -CH3 and -H; RebA, which has the highest sweetness and taste, the purity is not high enough in TSG85 and TSG90, and some of the minor glucosides component are bitter substances with hydrophobic groups, so there is a clear difference in taste with sugar.

With the increase of total Stevia glycosides content and purity of RebA, such as TSG85→TSG95/RebA60, the taste and sweetness have been significantly improved. Therefore, in the TSG series, TSG95/RebA60 is the preferred choice.

Regulatory reference: The United States FDA-GRAS used Stevia glycosides as a sweetener content standards require TSG ≥ 95%, JECFA standards also stipulated that stevioside used as a sweetener, the total Stevia glycosides content TSG ≥ 95%, international application examples in the solid drink, the TSG95/RebA60 is the product of choice for the majority of the threshold.

Second generation stevia monosaccharide, recommended RebA 97%~99%

Stevia glycosides in the natural composition of the leaves, Rebaudioside A (RebA) and Stevioside as the main components: RebA accounts for about 50% of the total Stevia glycosides in leaves, about 350 times the sweetness than sugar, taste is relatively pure. Stevioside accounts for about 30% of total Stevia glycosides, 180 times the sweetness, and its taste is not as good as RebA. Other mono-glycosides such as RebD, sweetness 350-400 times, taste better than RebA, but account for 1.2% of the total glycoside content or even lower. The RebM taste is comparable to sucrose, 350-400 times sweeter than the RebD.

Based on the demand for improved taste, high-purity refining and joint application from RebA → RebM has gradually emerged. Rebaudioside A (RebA) has become mainstream specifications for the stevia market due to thegood taste, commercial availability, and appropriate cost, with recommended specifications of RebA97% and RebA99%.

Third generation: high purity steviol glycoside combination

There is always a suitable for you with the in-depth development of steviol glycoside products, it has been found that when combined with different mono-glycosides such as RebA+RebB, RebA+RebC, RebA+RebD, RebA+RebM, etc., the taste of Reb A glycosides can be significantly improved and the price can also have advantages for some choices.

Fourth generation: Glucosyl Stevia

The introduction of some new glucose-based molecules into the structure of steviol glycosides by enzymatic or fermentation methods can improve the bad taste of natural steviol glycosides and give glucose-based steviol glycosides (Glucosyl Stevia) improved sweet taste characteristics. This technology has been used in Japan since the 1890s. Nowadays, the uses of glucose-based steviol glycosides as taste modifier or flavor enhancer is very mature in Japan and South Korea.

In China, glucosyl stevioside GSG75 was classified as a natural spice in the Health and Welfare Committee’s announcement No. 8 of 2016, and it was stipulated that it should be used as a spice in foods. In the United States, Glucose-based steviol glycosides TSG95 specifications can be used as tabletop sweeteners through the FDA-GRAS, and there are other specifications included on the FEMA-GRAS list for use as fragrances.

You can see that there are several generation and types of stevia products, commonly our sales of Rebaudioside A series, like RebA 97%, RebA 99% are higher than other types and specifications, we can understand from the market demand that the purity and good sweet taste is what our customers looking for and also their customers.

How to choose best suitable Steviol glycosides for your production is depends on your products requirement.

Posted on 15 Jun 2018
By Marketing
In Blog Article

Folic Acid Vitamin B9

What is Folic Acid?

Folic acid is a form of folate (a B vitamin, Folic Acid is chemical synthesized while Folate is from natural food) that both human beings and animals need. It is water soluble and also called Vitamin B9. Folic acid is important for pregnant it protects unborn babies against serious birth defects. Folic acid powder is used multi-vitamins products and fortified foods, such as breads, pastas and cereals, beverages, soft drinks and baby foods.

Property

Vitamin B9 Folic Acid is a yellow or orange yellow crystalline powder, odorless and tasteless, insoluble in water, ethanol, acetone, chloroform and ether, but freely soluble in dilute solutions of alkali hydroxides or carbonates. Folic Acid is a member of the B vitamin family that widely used in feed, food and nutraceutical applications. The natural form Folate is found in many foods including dark leafy vegetables, fruits and animal.

Molecular Formula

C19H19N7O6

Chemical structure

Molecular Weight

441.40

CAS No.

59-30-3

Another name for folic acid

5′-methyltetrahydrofolate, 5′-MTHF, Acide Folique, Acide Ptéroylglutamique, Acide Ptéroylmonoglutamique, Acido Folico, B Complex Vitamin, Complexe Vitaminique B, Dihydrofolate, Folacin, Folacine, Folate, Folinic Acid, L-methylfolate, Methylfolate, Pteroylglutamic Acid, Pteroylmonoglutamic Acid, Pteroylpolyglutamate, Tetrahydrofolate, Vitamin B9, Vitamine B9.

Is folic acid a B vitamin?

Yes, Folic Acid is a B vitamin and is often used in combination with other B vitamins in vitamin B complex formulations. Vitamin B complex generally includes vitamin B1 (Thiamine Hydrochloride and Thiamine Mononitrate), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (D-Calcium Pantothenate), vitamin B6 (Pyridoxine Hydrochloride), vitamin B7 (D-Biotin), vitamin B12 (cyanocobalamin) and Vitamin B9 (Folic acid).

Types of folic acid Vitamin B9

Depends on Folic acid Vitamin B9 is food grade or feed grade or pharmaceutical grade, commonly in the market the types of folic acid according to different folic acid content: 10%, 80% and pure as raw material. As a folic acid manufacturer and supplier, we sell the main types in the market:

folic acid pure powder
80% folic acid powder
10% folic acid powder

Vitamin B9 Folic acid Synthesis/manufacturing process

Following Raw materials are used during Vitamin B9 Folic acid Synthesis/manufacturing process: three chloro acetone, sodium carbonate, three aminopyrimidine sulfate, caustic soda, p-Aminobenzoyl glutamic acid, sulfuric acid, activated carbon.

Why take Folic acid when pregnant and what does folic acid do during pregnancy?

Vitamin B9 Folic acid is a water-soluble B vitamin, and the demand for folic acid in pregnant women is 4 times higher than normal people. Why take Folic acid when pregnant is that the early pregnancy period is the critical period of placental formation, cell growth, cleavage and the differentiation of the fetal organ system. Folic acid deficiency in pregnancy can lead to fetal malformation. For example, in China, the incidence of neural tube defects is about 3.8, including anencephalon, spina bifida, and so on. It may also cause early spontaneous abortions.

By the second trimester, during the third trimester, in addition to fetal growth and development, maternal blood volume, breast and placental development have increased the need for folic acid. Folate deficiency, pregnant women prone to placental abruption, pregnancy-induced hypertension syndrome, megaloblastic anemia; fetal prone to intrauterine growth retardation, premature delivery and low birth weight, and such fetal growth and mental development after birth will be subject to influences.

Before preparing to conceive, expectant mothers and fathers should maintain a happy mood in addition to basic smoking cessation and alcohol abstinence. Women who are preparing to become pregnant should start taking 400 μg of folic acid daily before pregnancy. American researchers found that if women begin to take folic acid early in pregnancy, the risk of cleft lip in future infants can be reduced. In addition, it is important for expectant mothers to take vitamins correctly during pregnancy, compound vitamins (rich in vitamins A, B6, B12, C, folic acid) and minerals (1000 mg of calcium, 500 mg of magnesium) is also very important to prevent baby’s brain and nerve defects.

What does folic acid do in the body?

Vitamin B9 Folic acid d0 a lots work in our body and the role it mainly plays as follows:

As a co-enzyme for the one-carbon unit transferase system in biochemical reactions, Folic acid plays as a one-carbon unit transferor.
Participate in the synthesis of purine and thymine, and further synthesize DNA and RNA.
Involved in amino acid metabolism, Folic acid function as a carrier for one carbon unit during the interconversion between glycine and serine, histidine and glutamic acid, homocysteine and methionine.
Folic acid helps synthesis of hemoglobin and methyl compounds such as epinephrine, choline, creatine and the like.
Folic acid plays an important role in the synthesis of proteins, nucleic acids and metabolism of various amino acids.
Folic acid helps purine and pyrimidine synthesis: As a coenzyme involved in the synthesis of purines and pyrimidines in nucleic acid synthesis, it plays a role in cellular DNA synthesis.
Folic acid helps amino acid transformation: Involvement in the conversion of two-carbon amino acids and three-carbon amino acids. It promotes the conversion of phenylalanine and tyrosine, histidine and glutamic acid, cysteine and methionine. In addition, folic acid is also a component containing iron hemoglobin.

Vitamin B9 Folic acid recommended daily intake

The recommended daily intake of folic acid in the US is 400 micrograms from foods or dietary supplements and the most over-the-counter supplements of folic acid are 400 mcg tablets. The U. S. Public Health Service and CDC recommend that all women of childbearing age consume 0.4 mg (400 micrograms) of folic acid daily to prevent two common and serious birth defects, spina bifida and anencephaly. 400 micrograms is the amount of folic acid during pregnancy.

Vitamin B9 Folic acid deficiency

Vitamin B9 Folic acid deficiency can lead to the block of forms of deoxythymidylate, purine nucleotides, and the interconversion of amino acids. And DNA synthesis will be reduced intracellular, and the disorder of cell division and maturation, causing megaloblastic anemia. Vitamin B12 deficiency and folic acid deficiency are basically similar, all can all cause megaloblastic anemia, white blood cell and thrombocytopenia, and gastrointestinal symptoms such as loss of appetite, abdominal distention, diarrhea, and glossitis, etc, with the most prominent glossitis, red tongue. The tongue papilla is atrophic and has a smooth surface, commonly known as “tongue tongue”, with pain.

Vitamin B12 deficiency is often accompanied by nervous system performance, such as fatigue, numbness of hands and feet, sensory disturbances, walking difficulties and other peripheral neuritis, subacute or chronic degeneration of spinal cord combined with the performance of the posterior lateral cord; Folic acid deficiency common in pernicious anemia, pediatric and elderly patients often appear Mental symptoms such as cravings, drowsiness, or confusion.

Vitamin B9 Folic acid deficiency can cause emotional changes, but the deficiency can disappear if take folic acid supplement. The deficiency of folic acid in pregnant women can increase the prevalence of preeclampsia and placental detachment. Pregnant women with megaloblastic anaemia are prone to intrauterine growth retardation, premature delivery and low birth weight. Deficiency of folic acid in early pregnancy can lead to fetal neural tube defects (such as spina bifida, anencephaly, etc.). Folic acid deficiency can also cause hyperhomocysteinemia, thereby increasing the risk of cardiovascular disease. Intestinal diseases can interfere with the absorption of folic acid in foods and the recycling process through the enterohepatic circulation, so folic acid deficiency is a common complication of small bowel disease.

Too much folic acid Vitamin B9

Vitamin B9 Folic acid is a water-soluble vitamin that is considered generally safe if intake not too much, for example, 20 times the adult minimum requirement. The excessed/too much Folic acid bound to polypeptide in serum and tissue will excreted in the urine. The toxic effects of taking large doses of folic acid may as follows:

Interfering with the effects of anticonvulsant drugs induces convulsive seizures.
Oral intake 350 mg of folic acid may affect the absorption of zinc, leading to zinc deficiency, retarding fetal development and increasing the number of low birth weight infants.
Covering the early manifestations of vitamin B12 deficiency causes damage to the nervous system.

How is Folic acid metabolism in body?

After being absorbed in the intestine, Vitamin B9 folic acid enters the liver through the portal vein and is converted into active tetrahydrofolate by the action of intrahepatic dihydrofolate reductase. The latter is the carrier that transfers the “one carbon group” in the body and is the main factor in DNA synthesis. After orally intake, it is almost completely absorbed in the gastrointestinal tract (mainly in the upper part of the duodenum), appears in the blood 5-20 minutes later, and reaches the highest plasma concentration after 1 hour. Most of Folic acid is stored in the liver, and folic acid in the body is mainly decomposed into purine and p-aminobenzoyl glutamic acid.

The plasma half-life is about 40 minutes. Folic acid discharged from the bile to the intestine can be absorbed again, forming a hepatic intestine circulation. In chronic alcoholism, the daily intake of folic acid (Folate) from food is greatly limited, and the enterohepatic circulation of folic acid may also be impaired by the toxic effects of alcohol on hepatic parenchymal cells.

Vitamin B9 Folic acid Function

Vitamin B9 Folic acid is involved in many functions but especially in the formation of red blood cells and in the normal development of the neural tube – the structure that becomes the brain and spinal cord in the foetus. Folic acid main functions as follows:

Help body use amino acids, the building blocks of proteins
Help body produce nucleic acids (like DNA), the body’s genetic material
Form blood cells in the bone marrow to
Ensure rapid cell growth in infancy, adolescence, and pregnancy
Control (together with vitamin B6 and vitamin B12) blood levels of the amino acid homocysteine, associated with certain chronic conditions like heart disease.

Vitamin B9 Folic acid Benefit

Vitamin B9 Folic acid benefits not pregnant

Vitamin B9 Folic acid is a kind of B vitamin. It slightly soluble in water, unstable to heat, light and acidic solution, stable to heat in neutral and alkaline solution, and loss up to 50~90% during cooking. Folic acid can not only benefit pregnant but also have other benefits:

Folic acid is a coenzyme help the synthesis of nucleic acids. The nucleic acid synthesis and normal cell division and replication will be affected if Folic acid deficiency.
Folic acid helps regulate the development of embryonic neurons and prevents newborn infants from developing congenital neural tube defects.
It (with Vitamin B12) is a must for the production of red blood cells and prevent the treatment of folate anemia.
Protecting the mucous membranes and mucous membranes is a very active part of cell division, decline, and regeneration.
Folic acid helps anti-cancer effect, and together with niacin can prevent free radicals from damaging the chromosomes.

Vitamin B9 Folic acid Side effects

Vitamin B9 Folic acid is LIKELY SAFE for most people when taken by mouth or injected into the body. Most adults do not experience any side effects when used in doses less than 1000 mcg daily.
Folic acid is POSSIBLY UNSAFE when taken by mouth in large doses, long-term. High doses of folic acid might cause abdominal cramps, diarrhea, rash, sleep disorders, irritability, confusion, nausea, stomach upset, behavior changes, skin reactions, seizures, gas, excitability, and other side effects.

Reference: https://www.webmd.com/vitamins/ai/ingredientmono-1017/folic-acid

Vitamin B9 Folic acid Use

In Food

Food grade Folic acid can be used in nutrition fortified foods such as Folic acid bread, folic acid milk, folic acid chewing gum, folic acid drink and folic acid flour, breakfast cereals and baby foods.

In feed

Vitamin B9 Folic acid consumption in feed takes a large part of total folic acid, around 75%. Feed grade folic acid can be used as feed additives and has a significant role in feed. Feed additives are raw materials that must be used in the modern feed industry. It has obvious effects on strengthening the nutritional value of the basic feed, improving animal production performance, ensuring animal health, saving feed costs, and improving livestock product quality. Folic acid is originally isolated from plants, so it is called folic acid and it is involved in the metabolism of substances in the animal’s body in the form of tetrahydrofolate. The transfer of a carbon group participates in the synthesis of pyrene, pyrimidine, and amino acid metabolism, thereby affecting the synthesis of nucleic acids and the metabolism of proteins, promoting the formation of normal blood cells, and promoting the production of immunoglobulins.

Vitamin B9 Folic acid deficiency in animals often causes anemia, decreasing of red blood cells, slow or stopped stopped. The symptoms like spinal palsy, feather decoloration, reduced reproductive capacity and high embryonic mortality will exist in birds. Particularly noticeable is the embryo’s temporal bones are short and staggered; pigs will have dermatitis and the symptoms of hair removal and the hurt digestive organs, respiratory organs and urinary mucosa.

Vitamin B9 Folic acid is one of the B vitamins, which can promote the maturation of young cells in bone marrow, promote growth and promote the formation of hematopoietic factors. Folic acid has the effect of promoting ovulation and increasing the number of follicles. Folic acid is added to the sow’s feed to increase the litter size. Folic acid is added to the feed of laying hens to increase the egg production rate.

Recommended dosage in feed

Piglet	0.6～0.7mg/kg	Growth Fei Yuzhu	0.3～0.6mg/kg
fish	1.0～2.0mg/kg	chick	0.6～0.7mg/kg
Laying hens	0.3～0.6mg/kg	Laying hens	0.3～0.6mg/kg
broilers	0.6～0.7mg/kg	–	–

In Pharmaceuticals and Healthy foods

In the pharmaceutical industry, folic acid is essential for the growth and reproduction of cells in the human body. It plays an important role in the metabolism of the human body and is one of the indispensable nutrients for the human body, especially for pregnant women, nursing mothers and infants who account for a large proportion of the population. Young children also need to supplement with folic acid. Folic acid is a significant drug for megaloblastic anemia. Therefore, there is a very broad market prospect for the development of folic acid pharmaceuticals and folic acid health foods.

What is Folate?

Folate and Folic acid are often used interchangeably but there are differences between them. Folate is the naturally-occurring form of the vitamin B9.

Food sources of Folate

Vegetables source

Good sources of folate from lettuce, spinach, asparagus, broccoli, rape, bok choy, greens, lentils, pods, tomatoes, carrots, squash, mushrooms, etc.

Fruits source

oranges, strawberries, cherries, bananas, lemons, peaches, plums, apricots, bayberry, jellyfish, wild jujube, hawthorn, pomegranate, grapes, kiwi, pears, walnuts, apples, etc. These are good sources of folate from fruits.

Animal foods source:

Folate rich foods in animal liver, kidney, poultry meat and eggs, such as liver, beef, lamb, chicken, egg yolk and so on.

Beans, Nuts source

Soybeans, soy products, walnuts (including walnut oil), cashews, chestnuts, almonds, pine nuts, etc.

Cereals source

Cereals foods high in folate whole wheat flour, barley, rice bran, wheat germ, brown rice and so on.

Is Folate better than Folic acid?

Folic aid is the synthetic form of the vitamin B9 that is used in most supplements and in fortified foods. (If your supplements lists “folate,” it suggests that food sources were used instead of synthetic folic acid.) The chemical structure of Folic acid is different with Folate.

Folic acid and folate work the same in the body, with one exception: Ironically, the synthetic form (folic acid) is better absorbed by the body than the natural form.

Interestingly, folic acid tends to be absorbed better than the folate found in food.

Many people think that natural Folate is better than Folic Acid as Folate is nature and more reliable than synthetic Folic acid. But if you look at the list of ingredients for the vitamin tablets you take every day, you’re more likely to see Folic Acid instead of Folate. This is because the Folic Acid absorption is more than twice that of Folate (natural folic acid). This does not mean that Folic Acid is better. The reason why manufacturers like to take Folic Acid to multivitamin supplements is that it can quickly relieve Folate deficiency and reduce the likelihood of congenital malformations in babies. And this is the reason pregnant choose to take Folic Acid to their diet during pregnancy.

Vitamin B9 Folic acid market

Market trend

It is expected that the application of Folic acid in health products and pharmaceutical products will drive the use of folic acid. Owing to the high medicinal value of folic acid, its consumption is expected to increase rapidly during the forecast period. Factors such as increasing health awareness and increasing awareness of the significance of folic acid for maintaining good health supports the growth of the folic acid market. Various health agencies also promote the use of folic acid in cereals products.

For example, the U.S. Department of Public Health and the Centers for Disease Control and Prevention recommend that all women of childbearing age take 0.4 mg (400 μg) of folic acid per day to prevent severe birth defects in children. The increasing purchasing power of consumers and their preference for nutritious and mineral-rich ready-to-eat foods may increase the demand for folic acid in the near future.

China is the big food and feed grade Folic acid manufacturers and export country in the world. China manufactures’ market takes around 90%.

Today’s price

Updated on 2018/05/26: Now the price for pure Folic acid powder is around RMB195/kg, the price in January was around RMB280/kg, it decreased around 30%.

Where to buy Vitamin B9 Folic acid?

You can buy food or feed grade Vitamin B9 Folic acid powder from us, Specification complies with BP/USP/EP/JP/FCC standard. As a Folic acid manufacturer and supplier, we sell food and feed grade Folic acid pure; 80% Folic acid and 10% Folic acid.

We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

Usage: feed additives, food additives, pharmaceuticals and healthy foods

Storage

It should be stored in a cool and dry place.
Avoid the sun and rain should be in the process of transportation, heating and impact.
Handling be careful not oxidizing and toxic or other polluting goods and material mixed, mixed transport.

Specification:

folic acid pure powder
80% folic acid powder
10% folic acid powder

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 9 Jun 2018
By Marketing
In Blog Article

D-Biotin Vitamin B7

What is Biotin (Vitamin B7)？

Biotin is a water-soluble B vitamin, also called vitamin B7 and formerly known as vitamin H or coenzyme R.

Biotin is essential for the synthesis of vitamin C and is an essential substance for normal metabolism of fats and proteins. Biotin can be found in all living cells. It is a nutrient to maintain the body’s natural growth, development and normal body functions.

Biotin is also required for the catabolism and utilization of the three branched-chain amino acids: leucine, isoleucine, and valine.

What’s the role of Biotin (Vitamin B7)

The human body needs about 100 to 300 mg D-Biotin per day. In raw egg white, there is an avidin protein (avidin) that binds with D-Biotin, and the combined D-Biotin cannot be absorbed by the digestive tract which will lead to the deficiency of D-Biotin in the animal body, that results in loss of appetite, glossitis, dermatitis, hair loss and so on.

However, the deficiency of D-Biotin have not yet be noticed in human beings, probably due to the fact that we intake foods high in Biotin or Biotin food sources; and intestinal bacteria can also synthesize D-Biotin. Biotin is a coenzyme of various enzymes in the human body, the role of Biotin involved in the metabolism of fatty acids and carbohydrates in the body; promoting the synthesis of proteins; also involved in the metabolism of vitamin B12, folic acid, pantothenic acid; and promoting urea synthesis and excretion.

Role of Biotin (Vitamin B7) and what it do?

Fat metabolism: help fat, liver sugar and amino acids in the human body for normal synthesis and metabolism;
Growth: promote the normal operation and growth of sweat glands, nerve tissue, bone marrow, male gonad, skin and hair, reduce eczema, dermatitis symptoms;
Prevent: Biotin prevent white hair and hair loss, help to treat baldness;
Ease muscle pain;
Promote urea synthesis and excretion, purine synthesis and oleic acid biosynthesis.
Treatment: help treatment of arteriosclerosis, stroke, lipid metabolism disorders, hypertension, coronary heart disease and blood circulation disorders.

Is Biotin (Vitamin B7) natural?

Biotin can be found in food, the type of Biotin is natural. Actually there are eight different forms of Biotin, but only one is naturally occurring — the kind found in food sources. This type is called “D-biotin” and is believed to be the only type that has full vitamin capabilities.

How many Types of Biotin (As raw material) in the market?

Depends on Biotin is food grade or feed grade or pharmaceutical grade, commonly in the market the types of Biotin are: 1%, 2%, 10% and pure as raw material. As a D-Biotin manufacturer and supplier, we sell the main types in the market:

D-biotin pure;
10% D-Biotin food grade (Maltodextrin as carrier);
2% D-Biotin feed grade (Maltodextrin as carrier)
1% D-Biotin feed grade (Dicalcium Phosphate as carrier)

How is Biotin (Vitamin B7) absorption in body?

By oral intake, Biotin is quickly absorbed from the stomach and intestine. 80% of the Biotin in the blood is present in free form. It is distributed throughout tissues of the body and the content will be more in the liver and kidneys. It is excreted through the urine and only a little quantity is metabolized to Biotin oxides and double-lowering biotin.

What is (Vitamin B7) Biotin deficiency?

Biotin deficiency means the low biotin intake, and the deficiency symptoms would be as follows:

increase the risk of dandruff, easy hair loss, juvenile white hair;
dull complexion, blush, dermatitis;
depression, insomnia, easy to sleep and other neurological symptoms;
fatigue, lazy weakness, muscle pain.
Signs of biotin deficiency: including dermatitis, eczema, atrophic glossitis, hyperesthesia, muscle pain, burnout, anorexia and mild anemia, hair loss

What is D-Biotin (Vitamin B7)

There are eight different forms of Biotin, but only D-Biotin is naturally occurring found in food sources. D-biotin is believed to be the only type that has full vitamin capabilities. The form of Biotin that your body can use is D-biotin.

The D, refers to chirality. Two molecules that are chiral isomers of each other will have the same chemical formula and structure; the only difference is the arrangement of groups around certain carbon atoms. It’s often easiest to think of chirality as “handedness”, so your left and right hands are chiral isomers of each other. Same structure, mirror images. Chirality does cause some difference in function.

Whenever you see “Biotin” in the supplement label or website or other place, it’s commonly means D-biotin. And the Biotin we talk in this article is D-Biotin which has full vitamin capabilities.

It is a B Vitamin, other B vitamins are Vitamin B1 (Thiamine Hcl), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin, Niacinamide), Vitamin B5 (Pantothenic acid), Vitamin B6 (Pyridoxine Hydrochloride), Vitamin B9 (Folic acid) and Vitamin B12 (Cyanocobalamin).

D-Biotin (Vitamin B7) Properties

Appearance and Solubility

D-Biotin is a white or almost white, crystal powder or colorless crystal, very slightly soluble in water and ethanol, practically insoluble in acetone. It can be dissolved in a dilute solution of alkaline hydroxide. Solubility in water: 22mg/100ml

Other Name

Biotin, vitamin H ,vitamin B7

CAS NO

58-85-5

MOLECULAR FORMULA

C10H16N2O3S

Chemical Formula

Where does (Vitamin B7) D-Biotin come from?

D-Biotin comes both from nature and chemical synthesis. Natural D-Biotin comes from food.

Food has biotin as follows

Beef or pork liver
Egg, cooked
Yeast
Whole wheat bread:
Avocado
Salmon
Cauliflower
Cheese
Etc

How is pure D-biotin (Vitamin B7) made in chemical synthesis?

Pure D-Biotin manufacturing process

Pure D-Biotin made by chemical synthesis and the manufacturing process as follows:

Naphthenic acid – Dehydration – Reduction – Sulfurization – Grignard Reaction – Hydrogenation – Debenzylation – Refining – D-biotin

1% 2% D-Biotin feed grade manufacturing process

Pure D-Biotin – Dissolution – Spray drying – Mixing – Sieving – D-Biotin 2% SD

Dissolve pure Biotin, Sodium carbonate and Carbohydrate in water. The solution is transferred into the spray drying chamber and a flow aid is added in order to achieve appropriate flowability. Feed grade D-Biotin 2% is then obtained after sieving.

Vitamin B7 D-Biotin Use

In Food

D-Biotin can be used in many dietary supplements, infant milk formulas and baby foods – as well as various dietetic products. D-Biotin is often used in combinations of the B vitamins. It can be used for human nutrition fortification, used for solid preparation, suitable for dry infusion with water.

What is biotin used for in the body?

Why do people take D-Biotin? Biotin can be used for promoting the synthesis of certain proteins by helping the production of energy; at the same time, it can help cells grow, produce fatty acids, metabolize carbohydrates, fats and proteins, and help the use of vitamin B; promoting sweat glands, nerve tissue, The health of bone marrow and male gonads maintains the normal operation and growth of skin and hair, relieves eczema and dermatitis symptoms, prevents white hair and hair loss, helps to treat baldness, eases muscle pain, and definitely helps melancholia and insomnia. Participate in the metabolism of vitamin B12, folic acid, pantothenic acid; promote urea synthesis and excretion; improve the body’s immune function.

In Cosmetics

D-Biotin market for cosmetics is developing and the beauty and cosmetics industry is one of the major international industries. As a D-Biotin manufacturer and supplier, our customers are mainly in the field of cosmetics and feed.

D-Biotin has an excellent cosmetic effect, it can keep skin white and nails smooth. The total international sales of cosmetics and cosmetics related products are much higher than the sales of pharmaceuticals. New applications of biotin in the skin, nails and hairdressing will inevitably lead to pharmaceutical-grade organisms.
D-Biotin as a nutritional supplement, can be used as a B Vitamin in the food industry. It has the function of preventing skin diseases and promoting lipid metabolism in cosmetics use.

It can increase the blood circulation speed in skin blood vessels. It is easy to mix the oil phase in the formula with concentration range from 0.1% to 1.0%. It can be used in skin creams, sports liquids, foot antiperspirants, shave lotions and shampoos in cosmetics use.

In Feed

D-Biotin is one of the B vitamins necessary to maintain normal physiological functions in the animal’s body. D- Biotin can be widely seen in feed additives plus animal intestines can synthesize D-Biotin, it was previously thought that it’s okay if animals feed do not add D-Biotin. However, D-Biotin deficiency often occurs especially under intensive production conditions, and D-biotin deficiency symptoms are more likely to occur.

The deficiency of D-biotin in livestock and poultry results in slow growth, reduced feeding, decreased breeding performance of female animals, and meat quality as well. Carcass week, dermatitis, and even death will also happen. The intake of D-biotin can improve the above symptoms. As a result, people re-emphasize and study the nutritional effects of D-biotin and its mechanisms. In recent years, D-biotin has become one of the most popular water-soluble B vitamins.

D-Biotin Properties

d-Biotin can be found in plants and animals, and naturally occurring D-biotin exists mainly in combination with other molecules. Its chemical structure includes a carboxyl side chain containing five carbon atoms and two five-membered heterocycles, which binds to the ε-lysine residue of the enzyme protein in the body and acts as a coenzyme. Biotin may have 8 different isomers, of which only D-biotin has biological activity. In animals, cells often exist in the free state or in combination with proteins.

D-biotin nutrition mechanism

D-Biotin has both bound and free forms. The bound biotin cannot be used directly by the animal and must be decomposed by the biotin-degrading enzymes of the intestine to release free biotin before it can be used by animals. Biotin is well absorbed in the small intestine and is absorbed in intact molecules in the 1/3 to 1/2 segments of the small intestine. The porcine stomach cannot absorb biotin, the small intestine is the main site of absorption, and the colon can also absorb biotin, while chickens absorb biotin mainly in the small intestine. Almost all cells have biotin and the content in the liver and kidneys is relatively high.

The content of biotin is related to the biochemical effects of cells. Isotope markers indicated that the content of biotin in the proximal epithelial cells, hepatocytes, intestinal villus epithelial cells, and adipocytes of the kidneys is high, while the contents in some rapidly proliferating cells such as renal cortical cells, bone marrow cells, and lymphocytes are low. When pigs are fed diets supplemented with biotin, the concentration of biotin will increase in the liver, kidneys and heart. When the D-biotin intake is more than necessary, the exceeded will are excreted through the urine. Unabsorbed biotin in feed will be discharged from feces.

D-biotin Function

D-Biotin is a coenzyme component of sacetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase four carboxylase. It also play an important role in glucose, amino acid and fatty acid metabolism in animals, like in human beings.

D-Biotin and Carbohydrates metabolism: In gluconeogenesis, pyruvate carboxylase, which uses biotin as a coenzyme, is a key enzyme in pyruvic acid to produce butanion acid. Therefore, when the supplement of D-Biotin in the feed is insufficient, the glycogen will be quickly depleted or reduced, and hypoglycemia will occur. Especially, the glycogen stores in the chicks are relatively small and often leads to death.

D-Biotin and fat metabolism: In the process of fat metabolism, biotin acts as a coenzyme for acetyl-CoA carboxylase and catalyzes the formation of malonyl-CoA from acetyl-CoA. In the deficiency of biotin, abnormal lipid metabolism results in changes in the body’s fatty acid composition, reduced synthesis of saturated fatty acids, and increased synthesis of triacylglycerols, resulting in significant increases in lipids in the liver and kidneys.

Biotin and proteins, nucleic acids metabolism: biotin plays an important role in protein synthesis, amino acid decarboxylation, purine synthesis, carbamoyl transfer, and leucine and tryptophan catabolism, and is also required for the transfer and decarboxylation of many amino acids. Biotin not only participates in the carboxylase metabolic pathway, but also affects gene expression. The deficiency of biotin in animals will lead to slow cell proliferation, impaired immune function, and abnormal embryonic development.

Vitamin B7 D-Biotin Uses FAQ

Can you take D-Biotin while pregnant?

D-Biotin is considered safe during pregnancy and is available without prescription. D-Biotin supplement can avoid the deficiency as more Biotin needed during pregnancy. It is generally safe but better consult your doctor before taking any new supplement while pregnancy.

Can you take too much D-Biotin?

Better not take too much D-Biotin daily. D-Biotin is a water-soluble vitamin, your body does not store the excess quantity. This means if you take too much biotin than you need via supplementation, your body will likely release the extra biotin in your urine.

D-Biotin recommended daily intake

The U.S. Institute of Medicine recommended daily intake and how much D-Biotin can take as follows:

Life Stage	Age	Males: (mcg/day)	Females: (mcg/day)
Infants	0–6 months	5	5
Infants	7–12 months	6	6
Children	1–3 years	8	8
Children	4–8 years	12	12
Children	9–13 years	20	20
Adolescents	14–18 years	25	25
Adults	19 years and older	30	30
Pregnancy	all ages	–	30
Breast-feeding	all ages	–	35

The European Food Safety Authority (EFSA) suggest for women and men over age 18, the Adequate Intake is set at 40 μg per day. The AI for pregnancy is 40 μg per day, and 45 μg per day during breastfeeding. For children ages 1–17 years, the AIs increase with age from 20 to 35 μg per day.

Reference: https://en.wikipedia.org/wiki/Biotin

How much D-Biotin do you need?

How much you need depending on your situation, your doctor might recommend a higher dose. Even at high levels, biotin appears to be fairly safe. Researchers don’t know at what dosage biotin might start to pose health risks.

How much D-Biotin is too much?

200mg is too much. There are currently no published medical reports of biotin toxicity. Although according to the National Institute of Health, doses as high as 200 mg have been used without significant adverse effects. However, the National Institute of Health recommends that higher doses than the recommended AI should not be taken without medical supervision.

Reference: https://www.fitday.com/fitness-articles/fitness/how-video-games-can-actually-be-good-for-your-mental-health.html

How much D-Biotin is safe?

The recommended daily intake of Biotin is 30 micrograms (0.03 mg). For most individuals, supplementation is not necessary to avoid deficiency as biotin is found in most commonly natural foods.

However, biotin supplementation in large doses, sometimes over 50 times the recommended daily intake, is very popular to support hair, nail and skin growth. While evidence is mixed regarding just how well biotin works in this regard, studies show that biotin is extremely safe, even in large doses, and is unlikely to cause serious adverse events.

Reference: https://www.pharmacistanswers.com/questions/can-you-too-much-biotin

How much D-Biotin daily for hair growth?

Keratin is a basic protein that makes up your hair, skin, and nails. It’s clear that biotin improves your body’s keratin infrastructure. But beyond that, researchers aren’t really sure what biotin’s role in hair or skincare is.

Research on the effects of biotin on hair growth is sparse. To date, there’s only limited evidence to suggest that increased biotin intake may help promote hair growth.

Reference: https://www.healthline.com/health/biotin-hair-growth

How much D-Biotin should i take for hair loss?

The current recommended dosage of Biotin in Europe is set at 50 mcg/day. And how much Biotin should you take for hair growth may be some sort of a confusion regarding reference values because Europe and the USA have different numbers. The average intake from foods that contain Biotin in most western populations is about 35–70 mcg/day, showing that most people in these countries consume sufficient amounts of Biotin.

Biotin is a popular supplement for hair, skin, and fingernails, though there is little evidence to suggest that taking biotin supplements can stop hair loss or stimulate hair or nail growth. Similarly, using biotin shampoo or other hair products is unlikely to produce any benefit. There is some evidence that taking biotin supplements with other medications may help control hair loss that’s associated with childhood alopecia.

Reference: https://www.everydayhealth.com/drugs/biotin

D-Biotin nutrition facts

Nutrition Facts
100g D-Biotin
Calories 0	Calories from Fat 0(%)
	% Daily Value *
Total Fat 0g	–
Sodium 0mg	0%
Carbohydrates 0g	–
Net carbs 0g	–
Fiber 0g	0%
Protein 0g
Vitamins and minerals
Vitamin A 0μg	0%
Vitamin C 0mg	0%
Calcium 0mg	0%
Iron 0mg	0%
Fatty acids
Amino acids

Is D-biotin only for females?

Obviously not, D-Biotin is both for females and males. Biotin is a B Vitamin which is recommended for men and women.

Vitamin B7 D-Biotin Function and Benefits

What is the function of D-Biotin in body?

Convert food into glucose, which is used to produce energy
Produce fatty acids and amino acids (the building blocks of protein)
Activate protein/amino acid metabolism in the hair roots and fingernail cells.

What is the benefits of D-Biotin in body?

The European Food Safety Authority (EFSA), which provides scientific advice to policy makers, has confirmed that clear health benefits have been established for the dietary intake of biotin (vitamin B7) in contributing to:

Normal macronutrient metabolism
Normal energy yielding metabolism
The maintenance of normal skin and mucous membranes
The normal function of the nervous system
The maintenance of normal hair
Normal psychological functions.

Vitamin B7 D-Biotin Side effects

Biotin is a safe and nontoxic vitamin. It has not been associated with any serious side effects, even in large doses. The FDA reports that biotin is safe and well tolerated when taken by mouth in recommended doses. But some have the opinion that Biotin may have side effects and it is bad for us:

Acne
Allergic Reactions
Effects During Pregnancy
Frequency Of Urination
Diarrhea
Nausea
Increase Blood Glucose Levels
Drug Interactions
Eosinophilic Pleuropericardial Effusion
Acute Respiratory Problems

Reference: http://www.stylecraze.com/articles/serious-side-effects-of-biotin-on-your-health

Vitamin B7 D-Biotin market

The major drivers for the global biotin market are the increasing uses of biotin in food, feed and cosmetics products. This is majorly due to increasing awareness regarding benefits associated with biotin such as improved skin, food conversion into glucose, production of fatty acids and activating production of protein/amino acid metabolism in the fingernail cells and hair roots. Also, biotin supplements boosts hair and nail growth making nails thicker and less brittle, therefore increasing the usage of products with D-Biotin.

Vitamins Market in Feed

Vitamins are a huge family. There are dozens of vitamins known so far, which can be broadly divided into fat-soluble and water-soluble categories: fat-soluble vitamins including Vitamin A, Vitamin D,Vitamin E,Vitamin K and etc.; water-soluble vitamins including B vitamins, like Vitamin B1, Vitamin B2, Vitamin B5, Vitamin B6, Vitamin B12 and Vitamin C, Vitamin B7 (D-Biotin) , Vitamin B3, Folic acid, Choline and so on. The demand of Vitamin A, Vitamin E and Vitamin C are very large and the global annual demand is around 10,000 ton for each vitamin.

Vitamin B belongs to small demand category and the market demand in the vitamin family is small if compared with Vitamin A, Vitamin E and Vitamin C, like D- Biotin and Folic acid. The annual demand is in the 100 tons and 1000 tons respectively.

From our statistics, 45% of Vitamins are used as feed additives, and 30% in pharmaceutical & cosmetics and 25% in food and beverages. Except Vitamin B12, VitaminB1, inositol, Vitamin C, and other few varieties, more than 70% of the other Vitamins used as feed additives. And 75% of D-Biotin in the market are used in feed industry.

The market demand of feed additives will grow. Whether it is the expansion of population or the upgrading of food structure, the development of animal husbandry and raising the output level of animal husbandry will provide more fleshy for humans under conditions of limited and difficult to reverse cultivated land resources. Therefore, in the long run, the feed additive industry will continue to maintain growth. And the market of D-Biotin will also increase.

Vitamins Market in Food

Vitamins are more commonly used in functional beverages in the market. These beverages are based on water and are prepared by adding amino acids, Taurine, Caffeine, electrolytes, vitamins and other natural nutrients and adjusting their composition and content ratio. According to the nutritional needs of certain special populations, the functional drinks like sports drinks, nutrient drinks, and other specialty beverages. According to calculations, the growth rate of vitamin application & use in the food and beverage market in recent years (10%-15%) is faster than that of medical cosmetics (3%-5%) and feed additives (1%-2%). With the benefit from the rapid growth of functional beverage market, the market demand of Nicotinamide, Calcium pantothenate, B1, B6, VC and other vitamin is increasing.

Vitamin B7 D-Biotin manufacturers and price trend in 2017

China is the big food and feed grade D-Biotin manufacturers and export country in the world. China manufactures’ market takes around 90%.

Today’s price

Updated on 2018/05/26: Now the price for feed grade 2% D-Biotin is around RMB54/kg, the price in January was around RMB190/kg, it decreased around 75%.

The price of Pure D-Biotin was around USD 1900/kg to USD2200/kg at high level in 2017.

Where to buy Vitamin B7 D-Biotin?

You can buy food or feed grade Vitamin B7 D-Biotin from us, Specification complies with BP/USP/EP/JP/FCC standard. As a D-Biotin manufacturer and supplier, we sell D-biotin pure; 10% D-Biotin food grade (Maltodextrin as carrier); 2% D-Biotin feed grade (Maltodextrin as carrier) and 1% D-Biotin feed grade (Dicalcium Phosphate as carrier)

Usage: feed additives, food additives, cosmetic ingredients and pharmaceuticals

Specification:

D-biotin pure
10% D-Biotin food grade (Maltodextrin as carrier)
2% D-Biotin feed grade (Maltodextrin as carrier)
1% D-Biotin feed grade (Dicalcium Phosphate as carrier)

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 7 Jun 2018
By Marketing
In Blog Article

Vitamin B5 D-Calcium Pantothenate and Pantothenic acid

What is Pantothenic acid?

Pantothenic acid, also known as vitamin B5, is a water-soluble B vitamin. Pantothenic acid is an essential nutrient. Animals require pantothenic acid in order to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. The calcium salt of Pantothenic acid is called D-Calcium Pantothenate. It can be used as food additives, feed additives and pharmaceutical ingredients. As a supplier of D-calcium pantothenate, we supply high quality D-calcium pantothenate from China manufacturers.

Another name for pantothenic acid: VB5; pantothenic acid, pantothenate. Vitamin b5 scientific name:Pantothenic acid

pantothenic acid structure:

Good sources of vitamin b5 Pantothenic acid in food

Foods high in pantothenic acid include mushrooms, cheese, fish, avocados, eggs, lean pork, beef, veal, chicken, sunflower seeds, salmon, corn, cauliflower and sweet potatoes. Whole grains are major sources of pantothenic acid, but processing and refining grains may result in a 35% to 75% loss. Freezing and canning of foods result in similar losses

Coenzyme form of vitamin B5 pantothenic acid in body

Pantothenic acid is a metabolically active component of coenzyme A (CoA) essential for the metabolism of carbohydrates, fats, and proteins and for acyl carrier protein (ACP), a component of FA synthesis. Animals require pantothenic acid in order to synthesize Coenzyme A.

D-Calcium pantothenate VS Pantothenic acid

D-calcium pantothenate is a synthetic vitamin B-5 supplement manufactured from pantothenic acid. It is a more stable form of the vitamin b5 and is often used as a source of the vitamin B5 in multivitamin supplements. Calcium pantothenate, as it is a salt, it is more stable than pantothenic acid and it is often used in dietary supplements.

Pantothenic acid is a very unstable chemical that is easily degraded by exposure to light, heat, or acids. To stabilize pantothenic acid to make sure it won’t break down in a supplement, manufacturers combine it with calcium to make D-calcium pantothenate.D-calcium pantothenate is easily break down to pantothenic acid that the body can readily use.

There are several different chemicals identified as vitamin B5. The form of vitamin B5 that is active in living organisms is D-pantothenic acid. It’s the only form of vitamin B5 that actually serves any function in living cells.

Panthenol

Panthenol, also called pantothenol, is a stable alcohol analog of pantothenic acid (vitamin B₅), and is thus a provitamin of B₅. It is often used as a source of the vitamin in multivitamin supplements.

It also called D-Panthenol. It plays a key role in the human intermediary metabolism. Deficiency of Vitamin B5 can result in many dermatological disorders. D-Panthenol is applied in pharmaceutical industry and almost all types of cosmetic preparations. It cares hair, skin and nails.

What is vitamin B5 D-calcium pantothenate?

D-calcium pantothenate, also call Calcium D-pantothenate is a synthetic vitamin B-5 supplement manufactured from pantothenic acid. It is a more stable form of the vitamin b5 and is often used as a source of the vitamin B5 in multivitamin supplements.

Properties

D-calcium pantothenate is a white powder, no smelly odor, tastes a little bitter, has hydroscopic property. Its aqueous solution shows neutrality or slightly alkaline, easy to dissolve in water, slightly solvable in ethanol, almost can not dissolve in chloroform or aether.

Chemical formula

C18H32CaN2O10

Chemical structure

Molecular weight

476.53

CAS No.

137-08-6

D-calcium pantothenate solubility

Readily soluble in water, soluble in glycerol, somewhat soluble in ethanol and virtually insoluble in ether and chloroform.

vitamin B5 D-calcium pantothenate manufacturing process

The manufacturing process of D-calcium pantothenate consists of three steps of synthesis of β-alanine (intermediate), DL-pantolactone (intermediate) and D-calcium pantothenate. There are two commonly used synthetic processes, one is DL. – Reaction of pantolactone with β-alanine to generate calcium DL-pantothenate, then resolved to calcium D-pantothenate; the other is the resolution of DL-pantolactone by chemical or biological methods. D-pantolactone reacts with β-alanine to produce calcium D-pantothenate. Among them, cyanide-containing waste water is more contaminated during the production of DL-pantolactone.

Vitamin B5 D-calcium pantothenate Function

Vitamin B5 D-calcium pantothenate function in the body

D-calcium pantothenate participates in the manufacturing of energy in the body and can control the metabolism of fat. It is an essential nutrient for the brain and nerves. It can help with the secretion of anti-stress hormones (steroids) in the body. It can keep skin and hair healthy.

D-calcium pantothenate helps cell formation, maintains normal development and development of the central nervous system; it is essential for maintaining the normal function of the adrenal glands; is essential for the conversion of fats and carbohydrates to energy; in the synthesis of antibodies, it helps human use of para-aminobenzoic acid and essential choline.

D-calcium pantothenate can strengthen the normal skin hydration function, improve dryness, roughness, desquamation, relieve itching, and treat various skin diseases (such as atopic dermatitis). Phosphorus, psoriasis, and contact dermatitis) related erythema effects.

Strengthen the skin barrier function: D-calcium pantothenate can promote normal skin keratinization and improve the skin’s tolerance to surfactants. Reduces discomfort caused by sensitive ingredients in cosmetics like burning, tingling, itching.

What does Vitamin b5 do?

Vitamin B5, also called pantothenic acid, is one of the most important vitamins for human life. It’s necessary for making blood cells, and it helps you convert the food you eat into energy. Vitamin B5 is one of eight B vitamins. All B vitamins help you convert the protein, carbohydrates, and fats you eat into energy.

Vitamin B5 Pantothenic acid absorption

When found in foods, most pantothenic acid is in the form of coenzyme A or bound to acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, coenzyme A and ACP are hydrolyzed into 4′-phosphopantetheine. The 4′-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid.

Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system.At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%.

Reference: https://en.wikipedia.org/wiki/Pantothenic_acid

Vitamin B5 Pantothenic acid metabolism

Pantothenates or alcohols, etc., are absorbed in the intestine and may be permeable to the small intestine. Pantothenic acid is part of the composition of coenzyme A. In tissues, pantothenic acid converts to co-enzyme A. Therefore, pantothenic acid is involved in fatty acid synthesis of steroids. It participates in the oxidation of pyruvate, alpha-ketoglutaric acid and fatty acids, and is also involved in the synthesis of fatty acids and steroids. Pantothenic acid acts on the adrenal glands, digestive tract, nerves and skin in the body.

Health Benefits of vitamin B5

D-Calcium pantothenate is used for prevention and treatment of D-pantothenic acid deficiency (e.g. by means of multivitamins or B-complex preparations). It is practical for preventing pantothenic acid deficiency as well as meeting particular nutritional requirements.

Deficiency of D-calcium pantothenate vitamin B5

In Humans

The deficiency of D-calcium pantothenate in humans has the following symptoms:

Growth stops, body weight decreases, and sudden death occurs.
Skin and hair disorders: hair fall
Neurological disorders.
Abnormal digestive organs, liver dysfunction.
Affecting antibody formation.

In Animals

In animal studies, the deficiency of pantothenic acid causes fetal reabsorption, abnormalities, stillbirth, corneal vascular lesions, bone lesions and so on.

The deficiency of D- calcium pantothenate in animals has the following symptoms：

The deficiency in pigs:

There are geese walking on the hind legs, and acne dermatitis is present at the tip of the nose and the eyes.
The hair becomes bald after it first loses color, and skin ulceration may occur when it deteriorates.
Degeneration of the nervous system causes paralysis.
Blood exudative rhinitis causes bronchopneumonia, bowel swelling, atrophy, and ulcers.
The liver is degraded due to fatty liver.
Kidneys have hemorrhagic necrosis.

Vitamin B5 D-calcium pantothenate Uses

Calcium D-pantothenate is mainly used as feed additives, food additives and pharmaceutical ingredients. Around 60% in global market are used in feed, 15% for veterinary drugs, 10% for pharmaceuticals, and 15% in food.

D- calcium pantothenate is often used in combination with other B vitamins in vitamin B complex formulations. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid.

In food

D-calcium pantothenate can be used to a number of food products, e.g. products for babies and small children, food products like energy drinks for athletes, low-calorie and calorie-reduced foods, vitamin-fortified juices, etc. We supply high quality D-calcium pantothenate in the dietary supplement, food, beverage and infant nutrition industries to suit customer needs.

Dietary daily recommendations

Age group	Age	Adequate intake
Infants	0–6 months	1.7 mg
Infants	7–12 months	1.8 mg
Children	1–3 years	2 mg
Children	4–8 years	3 mg
Children	9–13 years	4 mg
Adult men and women	14+ years	5 mg
Pregnant women	(vs. 5)	6 mg
Breastfeeding women	(vs. 5)	7 mg

In feed

Calcium D-pantothenate is a vitamin drug in the feed industry. It is a component of Coenzyme A that regulates the metabolism of proteins, carbohydrates, and fats, maintains skin and mucous membranes, improves the color of hair (or feathers), and prevents the occurrence of diseases. It is essential for the growth, development of poultry, livestock and fishes and their fat synthesis and decomposition.

The dosage in feed additives

Piglets: 10 to 15 mg/kg
Growing and finishing pigs: 10 to 15 mg/kg
Egg chickens: 10 to 15 mg/kg
Breeding layer: 10 to 15 mg/kg
Laying hens: 20 to 25 mg/kg
Broiler: 20 to 25 mg/kg
Fish: 20 to 50 mg/kg

In cosmetics

D-calcium pantothenate can improve hair growth and pigmentation and protects the skin. it can be used in cosmetics products such as in hair care products, sun care products, shaving lotions and baby care products.

Vitamin B5 D-calcium pantothenate Side effects

Pantothenic acid toxicity symptoms

Pantothenic acid is not known to be toxic in humans. The only adverse effect noted was diarrhea resulting from very high intakes of 10 to 20 g/day of calcium D-pantothenate.

Vitamin B5 D-calcium pantothenate market

D-calcium pantothenate manufacturers and price trend in 2017

China is the big food and feed grade Calcium pantothenate manufacturers and export country in the world. China manufactures’ market takes around 60%.

The calcium pantothenate products (calcium D-pantothenate and D-panthenol, vitamin B5 and pro-B5) are mainly used in the fields of feed, food and pharmaceutical industry. They are necessary for animal growth, promote the utilization of nutrients, promote the synthesis and decomposition of fatty acids, etc. , It is an important additive in animal feed.

D-Calcium pantothenate is mainly monopolized by oligopolists in China. In 2016, the global vitamin B5 production companies mainly include Yifan, Xinfa, Huachen, BASF, and DSM. The global demand is about 19,200 tons, and the China market demand is about 3,350 tons. The global production capacity is about 25,000 tons, China accounts for more than 60%, China’s calcium pantothenate exports amounted to about 12,700 tons in 2015.

Environmental Protection Supervisor Suddenly Overweights in Shandong and that makes Pantothenic Calcium Prices Come to Historical Highs in 2017.

Due to the difficulty in handling cyanide-containing waste water during the production of calcium pantothenate, environmental protection pressures are high for manufacturers. At the same time, the number and production capacity of highly polluting bulk drug manufacturers in Shandong Province ranks in the forefront in the country. Frequent accidents are the main reasons that environmental protection inspectors are concerned about.

In April 2017, two factories in Shandong province suspended production due to environmental protection verification for one month. In June 2017, due to chemical plant explosion accidents, Shandong province carried out safety rectification across the province and stopped production again. That’s drive the price of D-calcium pantothenate to a record high position of 750 yuan/kg.

In August-September 2017, the fourth batch of Central Environmental Protection Inspectors visited Shandong and Zhejiang. Two factories ceased production and restricted production. The “2+26” atmospheric special rectification plan started in September covered Shandong and Hebei again. In key chemical cities, Shandong Province plans to carry out a five-year chemical industry safety production transformation and upgrading project after the chemical plant explosion in June. It is to conduct comprehensive chemical industry inspections and strict law enforcement from June to the end of 2017.

It is therefore expected that two factories in Shandong will continue to slow their release rate. With regard to new capacity of Brother will use the self-developed bio-enzyme dismantling process for the first time. Production line debugging will take some time. It is expected that the fourth quarter of 2017 will be completed. The release rate of new calcium pantothenate production capacity is expected to be reasonable. It is expected that the release of production capacity will not exceed 2,000 tons per annum in 2017, ie the output in the fourth quarter of 2017 is not expected to exceed 500 tons. The process of resuming production of two factories in Shandong is still limited, and the pattern of calcium pantothenate supply shortage is unlikely to be significant during the year.

Today’s price

Updated on 2018/05/26: Now the price for feed grade is around RMB68/kg, the price in January was around RMB360/kg, it decreased more than 80%.

Where to buy D-calcium pantothenate?

You can buy food or feed grade D-calcium pantothenate from us, Specification complies with BP/USP/EP/JP/FCC standard.

Usage: feed additives, food additives

Specification: BP/USP/EP/JP/FCC
Packing: 25kg / carton
Storage: Store in a cool and dry place
Validity: Shelf life of three years.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 2 Jun 2018
By Marketing
In Blog Article

Vitamin B6 Pyridoxine and Pyridoxine Hydrochloride

What is Pyridoxine?

Pyridoxine, also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. Vitamin B6 Pyridoxine is required in small quantities to help our bodies grow, develop, and function properly.

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are able to synthesize pyridoxine through endogenous biological processes, animals must obtain it through their diet.

Other name for Pyridoxine

Vitamin B6,Vitamin B-6, B6, Pyridoxine, Pyridoxine HCl, Pyridoxine Hydrochloride, B Complex Vitamin, B6, Complexe de Vitamines B, Phosphate de Pyridoxal, Phosphate de Pyridoxamine, Piridoxina, Pyridoxal, Pyridoxal Phosphate, Pyridoxal 5 Phosphate, Pyridoxal-5-Phosphate, Pyridoxal-5′-Phosphate, Pyridoxamine, Pyridoxamine Phosphate, Pyridoxamine-5′-Phosphate, , Pyridoxine-5-Phosphate, Pyridoxine-5′-Phosphate, P5P, P-5-P, Adermine Chlorhydrate, Adermine Hydrochloride, Chlorhydrate de pyridoxine

Pyridoxine chemical formula

C8H11NO3

Pyridoxine molecular weight

169.18 g·mol−1

Pyridoxine structure

Is pyridoxine water soluble?

Yes, pyridoxine is water soluble like other vitamin B series: thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), biotin (B7), folic acid (B9), Vitamin B12.

Vitamin B6 Pyridoxine food source

The richest sources of vitamin B6 include fish, beef liver and other organ meats, potatoes and other starchy vegetables, and fruit (other than citrus).

Vitamin B6 has a wide range of food sources and is found in both animal and plant foods. Usually with higher levels in meat, whole grains (especially wheat), vegetables and nuts. The bioavailability of vitamin B6 in animal-derived foods is superior to that of plant-derived foods. In animal and plant foods, the content was slight, the content of yeast powder was the highest, and the content of rice bran or white rice was also high. The second was from meat, poultry, fish, potatoes, sweet potatoes, and vegetables.

The amount of vitamin B6 that can be eaten per 100 g of various foods is as follows: 3.67 mg of yeast powder, 2.91 mg of defatted rice bran, 2.79 mg of white rice, 1.25 mg of flax, 0.8 to 0.04 mg of cheese, 0.7 mg of carrot, and 0.45 mg of fish. , Wholemeal extract 0.4 ~ 0.7mg, meat 0.3 ~ 0.08mg, milk 0.3 ~ 0.03mg, egg 0.25mg, spinach 0.22mg, sweet potato 0.14 ~ 0.23mg, pea 0.16mg, soybean 0.1mg, orange 0.05mg.

Role of pyridoxine Vitamin B6

Vitamin B6 plays an important role in the body. Pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. It’s important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5′-phosphate, pyridoxal 5′-phosphate and pyridoxamine 5′-phosphate. Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine.

Action of pyridoxine or mechanism of action of pyridoxine

Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5′-phosphate (PNP), pyridoxal 5′-phosphate (PLP) and pyridoxamine 5′-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5′-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).

Reference: https://www.drugbank.ca/drugs/DB00165

Vitamin B6 pyridoxine functions

Vitamin B6 is one of the vitamins included in the vitamin B complex family. All B vitamins, including vitamin B6, play an important role in a range of physical and psychological functions.principally in its biologically active coenzyme form pyridoxal 5′-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).

Nearly 100 enzyme reactions are mainly involved in the form of pyridoxal phosphate (PLP). Most are related to amino acid metabolism: including transamination, decarboxylation, side chain cleavage, dehydration, and transvulcanization. Vitamin B6 Pyridoxine functions as follows:

Involved in protein synthesis and catabolism and in amino acids metabolism, such as the metabolism of heme, and tryptophan synthesis of niacin.
Participates in gluconeogenesis, UFA metabolism. Vitamin B6 Pyridoxine is related to the metabolism of glycogen, sphingomyelin and steroids.
Involved in the synthesis of certain neurotransmitters (serotonin, taurine, dopamine, norepinephrine, and gamma-aminobutyric acid).
Participates in the metabolism together with one carbon unit, vitamin B12 and folate, if they are metabolically degraded, can cause megaloblastic anemia.
Participates in nucleic acid and DNA synthesis. Lack of DNA synthesis can damage DNA synthesis. This process is very important for maintaining proper immune function.
Vitamin B6 and vitamin B2 is very close, Vitamin B6 deficiency is often accompanied by Vitamin B2 deficiency symptoms.
Participate in the conversion of homocysteine to methionine, which has the effect of reducing chronic diseases. Mild hyperhomocysteinemia is considered as a possible risk factor for vascular disease, and vitamin B6 intervention can reduce plasma homocysteine Cystine content.

Vitamin B6 Pyridoxine deficiency

Pyridoxine 5′-phosphate, vitamin B-6, is an essential cofactor in various transamination, decarboxylation, glycogen hydrolysis, and synthesis pathways involving carbohydrate, sphingolipid, amino acid, heme, and neurotransmitter metabolism. Pyridoxine deficiency causes symptoms, such as irritability, depression, and confusion have been noted; additional symptoms include inflammation of the tongue, open sores (‘ulcers’) inside the mouth, and ulcers of the skin at the corners of the mouth. Further symptoms are: microcytic anaemia, dermatitis, nervous/muscular signs, irritability, fatigue, numbness, headache, muscle twitching, difﬁculty walking, convulsions, depression and confusion

Vitamin B6 Pyridoxine pregnancy dose

Pyridoxine is also used for the treatment of nausea and vomiting in pregnancy.

Pyridoxine (vitamin B6) — Pyridoxine can improve nausea, has a good safety profile with minimal side effects, and is easy to obtain; therefore, we generally begin pyridoxine as the initial drug treatment.

As a single agent, the recommended dose of pyridoxine is 10 to 25 mg orally every six to eight hours; the maximum treatment dose suggested for pregnant women is 200 mg/day.

Reference: https://www.uptodate.com/contents/treatment-and-outcome-of-nausea-and-vomiting-of-pregnancy

What is Vitamin B6 pyridoxine used for?

Vitamin B6 Pyridoxine can be used with other B vitamins in many multivitamin preparations for adults and children and added to foods as a supplement to breakfast foods, power bars, and powders.

What is Pyridoxine hydrochloride?

Pyridoxine Hydrochloride, also called Pyridoxine Hcl, is the hydrochloride salt of pyridoxine, a water-soluble B vitamin.

It is a source of the essential B-complex vitamin pyridoxine. Pyridoxine hydrochloride is an important component of enzymes needed for protein metabolism. Besides building muscles, pyridoxine hydrochloride is also very important in helping Human beings and Animals body build protein structures like hair, nails, enzymes, and growth hormones.

Pyridoxine hydrochloride is converted in the liver into the metabolically active coenzyme form pyridoxal 5′-phosphate (P5P), an essential cofactor in many enzymatic reactions in amino acid metabolism, including transamination, deamination, and decarboxylation. P5P is required for glycogenolysis and the synthesis of sphingolipids and is essential to red blood cell, nervous system, and immune system functions.

Properties

Pyridoxine hydrochloride is white or almost white crystalline or crystalline powder; odorless, sour and bitter; Soluble in water, slightly soluble in ethanol. The aqueous solution is slightly acidic. Pyridoxine is an alcoholic vitamin that is a more stable structure that can be heat-resistant in acidic or alkaline solutions. It melts at about 205°C, with decomposition.

CAS No.

CAS No.58-56-0

Chemical structure

Chemical formula

C8H11NO3·HCl

Molecular weight

205.64

Solubility

Solubility in water (200 mg/ml at 20° C)

Pyridoxine hydrochloride benefits

Pyridoxine, or vitamin B6, is one of eight B vitamins. It helps the body convert food into fuel, metabolize fats and proteins, maintain proper functioning of nerves, and produce red blood cells. Vitamin B6 is found in many foods, is added to foods, and is available as a dietary supplement.

Pyridoxine hydrochloride Uses

In feed:Pyridoxine Hydrochloride can be used as feed additives to promote the growth and development of young animals;

In food: Pyridoxine Hydrochloride can be used in food and beverages to strengthen nutrition;

It cosmetics: it can promote hair growth and skin protection when used in cosmetics;

Pyridoxine hydrochloride uses in food

Pyridoxine Hydrochloride, also known as Vitamin B6 and Pyridoxine Hcl, is essential for numerous body and brain functions. It is commonly used in general food fortification and dietary supplement applications to reinforce nutrition in the food. The main uses in Milk powdered drink, Powdered drink, Cocoa powder and other nutritious solid beverages, Wine, Instant Breakfast, Jelly, Soft drinks, Infant foods and Nutritional formula powder for Pregnant woman and etc.

Vitamin B6 can be used to strengthen solid beverages, with a maximum dosage of 7-10 mg/kg; the usage in fortified infant foods at 3 to 4 mg/kg; the maximum amount used in fortified beverages is 1~2 mg/kg.

Uses & applications	Dosage or Usage
Milk powdered drink	1.20-1.58 mg/100 g
Powdered drink	0.007- 0.01 g/kg
Cocoa powder and other nutritious solid beverages	1-2.2 mg/100 g
Wine	1-2 mg/kg
Instant Breakfast	10-25 mg/kg
Jelly	1.0-7.0 mg/kg
Soft drinks	0.4-1.2 mg/kg
Infant foods	3-4 mg/kg
Liquid drink	1-2 mg/kg
Milk powder	8-16 mg/kg
Nutritional formula powder for Preschooler	0.2-0.4 mg/d
Nutritional formula powder for Pregnant woman	0.63-1.27 mg/d

Pyridoxine hydrochloride uses in feed

Vitamin B6 has the form of pyridoxal, pyridoxamine and pyridoxine, they have the same potency for animals, but the stability of the former two is poor, and vitamin B6 is usually means pyridoxine when as a feed additive and the form is Pyridoxine hydrochloride. Pyridoxine hydrochloride is very stable in the application of dry, inert carriers and various vitamin premixes. In the coexistence of choline chloride and trace element minerals, especially in the presence of trace element oxides and carbonates that react with alkalinity, pyridoxine hydrochloride is easily destroyed.

Pyridoxine hydrochloride is an important coenzyme in poultry, poultry can not synthesize vitamin B6, must be taken from the feed. Its deficiency is a nutritional metabolic disease characterized by decreased appetite, short bones, and neurological symptoms.

Pyridoxine hydrochloride uses in poultry

Vitamin B6 deficiency mainly causes protein and fat metabolism disorders, impedes the synthesis of hemoglobin, and damage to the nervous system, resulting in obstructed growth and development of poultry, causing anemia and degeneration of nerve tissue, and thus has poor growth, anemia, and characteristic neurological symptoms. The deficiency of vitamin B6, chicks mainly exhibit neurological symptoms: abnormal excitement, no purpose running, flapping wings, and sagging head. Then a generalized convulsions occurred, the movement was disordered, the body turned sideways, and the head, neck, legs and legs twitched, and finally died of exhaustion.

In addition, the diseased chicks suffer from poor appetite, slow growth, rough feathers, unkemptness, pale cocks, and anemia. Adult chickens suffer from loss of appetite, weight loss, decreased egg production, low hatching rate, anemia, atrophy of the crown, flesh, ovary, and testicles and eventually death. Ducks showed pale anaemia and generally had no neurological symptoms. Post-mortem examination of dead chickens with subcutaneous edema, enlargement of internal organs, degeneration of the spinal cord and peripheral nerves, and sometimes hepatic degeneration.

The suggested dosage in poultry is 3～5 mg/kg.

Pyridoxine hydrochloride uses in aquaculture

Pyridoxine hydrochloride is a necessary Vitamin to maintain the health of aquatic animals and promote growth and development. It cannot be synthesized or synthesized in the body by other substances and must often be fed by food. If the intake is insufficient in long-term or cannot meet physiological needs due to other reasons, it will lead to metabolic disorders of fish, shrimp, growth retardation and resistance to disease. The suggested dosage in aquatic animals is 3～50 mg/kg.

Pyridoxine hydrochloride uses in pet food

Pyridoxine hydrochloride is the most common form used when supplementing pet foods with the B-vitamin pyridoxine. Pyridoxine is very important in helping the pet metabolize protein. It can be used in dog and cat food, also it can be used in pig food. The suggested dosage in pig is 1～3 mg/kg.

Pyridoxine hydrochloride side effects

Pyridoxine hydrochloride is LIKELY SAFE for most people when used appropriately. Pyridoxine hydrochloride is POSSIBLY SAFE when taken by mouth in amounts greater than the recommended dietary allowance. In some people, pyridoxine hydrochloride might cause nausea, vomiting,stomach pain, loss of appetite, headache, tingling, sleepiness, and other side effects.

Reference: https://www.webmd.com/vitamins/ai/ingredientmono-934/pyridoxine-vitamin-b6

Although vitamin B6 is a water-soluble vitamin and is excreted in the urine, long-term supplementation with very high doses (excess of 1,000 mg per day) of pyridoxine may result in sensory neuropathy. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months. Yet, none of the studies in which an objective neurological examination was performed reported evidence of sensory nerve damage at intakes below 200 mg pyridoxine daily.

Pyridoxine hydrochloride Market

VB6 is a water-soluble B vitamin that is an important nutritional supplement for humans and animals. In recent years, with the deepening of clinical research, vitamin B6 has many new discoveries and new uses. Vitamin B6 can promote the absorption of amino acids and protein synthesis, is also involved in fat metabolism, mainly in clinical use for vitamin b6 deficiency; isoniazid poisoning; vomiting, anemia caused by pregnancy, radiation sickness and anti-cancer drugs; leukopenia and Seborrheic dermatitis and so on.

At present, the manufacturing process synthesis of pyridoxine hcl used in China is an improved oxazole method, and its raw materials involve L-alanine and oxalic acid and ethanol. With fewer steps, high yields, and easy quality control, the production cost is greatly reduced. Many domestic companies have adopted this technology, which has enabled China to rapidly expand its production scale, rapidly increase production, significantly reduce costs, and greatly increase market competitiveness.

Huge demand as feed additives

Vitamin B6 is an important feed additive, and it is used in a large amount in the international market, almost exceeding the amount of pharmaceuticals. China’s aquaculture industry also accelerates the development, and every year it needs to add more than 100 million tons of feeds such as various vitamins, accounting for about 50% of the total amount. It is expected that the rigid demand for feed additives such as VB6 in the domestic and foreign markets will be enormous.

Rich pharmaceutical-grade products

Vitamin B6 has become a widely used vitamin product in clinical applications. Its tablets and injections have been listed in China’s “National Basic Medical Insurance, Industrial Injury Insurance, and Maternity Insurance Drug List”, which are classified as Category B and Category A.

Vitamin B6 is also the first group of non-prescription drugs to enter China. There are more than 20 formulations of otc drugs that now involve vitamin B6. In addition to single tablets, there are compound nine-dimensional tablets, ten-dimensional tablets, Victoria iron tablets, children’s four-dimensional calcium glucomate tablets, multivitamin tablets, 14 multi-dimensional elements, 15 multi-dimensional elements, 16 multi-dimensional elements and so on. In addition to the treatment of diseases, health products almost occupied the vitamin B6 market, and the market sales were very large. In 2014, annual sales of vitamin B6 health products reached more than 80 billion yuan.

Pyridoxine hydrochloride manufacturers and price

China is the big food and feed grade Vitamin B6 manufacturers and export country in the world. China manufactures’ market takes around 70%.

At present, the annual demand for vitamin B6 is around 7,000 tons and the total production capacity is more than 9,000 tons. Last Q4, the fourth environmental inspector and Beijing-Tianjin-Hebei air pollution control have had a major impact on the normal manufacturing of VB6. More than 60% of all VB6 manufacturers are located in the fourth environmental protection inspection and 2+26 urban areas. On September 19, 2017, a fire accident happened in one of the producer and it was expected that it will take a long time when it resume production. (It is estimated the factory will resume soon, updated on 06/01/2018)

In addition, the export volume in the same period will increase by a large margin, which further exacerbates the tight supply situation of VB6. In the first half of 2017, the market price of VB6 was basically around RMB 240/kg. Starting from July, VB6 started the price increase. In July and August, it rose slightly by 3.1% and 5.0% respectively. In September, it rose by 30% within one month. October has risen 14% so far, and the price hike continues. Price updated on Sep/2017: The current price was 515 yuan/kg, which was 119% higher than the 235 yuan/kg at the beginning of the year.

Today’s price

Updated on 2018/05/26: Now the price for feed grade is around RMB280/kg, the price in January was around RMB520/kg, it decreased more than 50%.

Where to buy pyridoxine hydrochloride?

You can buy food or feed grade pyridoxine hydrochloride from us, Specification complies with BP/USP/EP/JP/FCC standard.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 2 Jun 2018
By Marketing
In Blog Article

Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium

What is Riboflavin?

Riboflavin is also known as vitamin b2, with the CAS No.83-88-5. As a supplement it is used to prevent and treat riboflavin deficiency and prevent migraines. It can be used as an deep yellow – orange – red food colouring with the E number E101. Riboflavin can also be used as a food and feed additive. When used to fortify foods, typical products include cereals, sauces, vitamin supplements, soups.

Vitamin B2 Riboflavin Property

Appearance

It is a yellow or orange yellow crystalline powder; smells slightly bitter; Slightly dissolves in water, not dissolve in ether, alcohol and chloroform, with the melting point of 281-290℃.

Riboflavin solubility

It is water soluble, but lower water solubility than other B vitamins.

Chemical formula of riboflavin

C₁₇H₂₀N₄O₆

Molecular weight

376.37 g·mol⁻¹

Chemical structure

Riboflavin assay

The assay depends on it is food/pharma/feed grade,

Food/pharma grade: BP/USP/EP/FCC, 100%
Feed grade: 80%

Riboflavin stability

Riboflavin (vitamin B2) is very stable during thermal processing, storage, and food preparation. Riboflavin, however, is susceptible to degradation on exposure to light. The use of light-proof packaging material prevents its deterioration.

Vitamin B2 Riboflavin in milk

Milk is the good source of Riboflavin and high with it. Milk contains the water soluble vitamins thiamin (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), vitamin B6 (pyridoxine), vitamin B12 (cobalamin), vitamin C, and folate. Milk is a good source of thiamin, riboflavin and vitamin B12 . Milk contains small amounts of niacin, pantothenic acid, vitamin B6, vitamin C, and folate and is not considered a major source of these vitamins in the diet.

Vitamin B2 Riboflavin and pregnancy

Why you need riboflavin during pregnancy. Riboflavin, or vitamin B2, is an essential vitamin that helps your body produce energy. It promotes your baby’s growth, good vision, and healthy skin. Riboflavin is also essential for your baby’s bone, muscle, and nerve development.

Reference: https://www.babycenter.com/0_riboflavin-in-your-pregnancy-diet_672.bc

Source of riboflavin: Meat products, vegetables and fruits

Riboflavin is found in a wide variety of foods. Enriched grains are good sources of riboflavin. Quinoa and some fruits and vegetables also contain rich riboflavin. Foods source such as seafood, lean meats and poultry, eggs, legumes (beans and peas), nuts, seeds, and soy products. Almonds, beef and lamb, Oily fish, egg, pork, mushrooms, sesame seeds, seafood, spinach.

This following table will show you sources of riboflavin. Milk and dairy products are the richest sources.

Food	Serving Size	Riboflavin (mg)
Vegetables and Fruits
Vegetables
Mushroom (white, portabello, crimini), raw or cooked	125 mL (½ cup)	0.2-0.6
Spinach, cooked	125 mL (½ cup)	0.2
Grain Products
Cereal, corn flakes	30 g (check product label for serving size)	1.1
Cereal, muesli	30 g (check product label for serving size)	0.2
Waffle	1 small (35g)	0.2
Milk and Alternatives
Milk (3.3% homo, 2%, 1%, skim)	250 mL (1 cup)	0.4-0.5
Cottage cheese	250 mL (1 cup)	0.4-0.6
Buttermilk	250 mL (1 cup)	0.4
Cheese, feta	50 g (1½ oz)	0.4
Yogurt beverage	200 mL	0.4
Yogurt (fruit, plain, Greek), all types	175 g (¾ cup)	0.2-0.4
Soy beverage	250 mL (1 cup)	0.4
Cheese (cheddar, monterey, edam, colby, blue, brie, camembert)	50 g (1½ oz)	0.2
Ricotta cheese	125 mL (½ cup)	0.2
Meat and Alternatives
Meat
Pork, various cuts, cooked	75 g (2½ oz)	0.2-0.3
Beef, various cuts, cooked	75 g (2½ oz)	0.2-0.3
Chicken or turkey, dark meat, cooked	75 g (2½ oz)	0.2
Organ Meats
Liver (chicken, turkey, pork, beef), cooked	75 g (2½ oz)	1.6-2.7
Fish and Seafood
Cuttlefish, cooked	75 g (2½ oz)	1.3
Salmon, cooked	75 g (2½ oz)	0.4
Mackerel, cooked	75 g (2½ oz)	0.3-0.4
Squid, cooked	75 g (2½ oz)	0.3
Trout, cooked	75 g (2½ oz)	0.3
Shellfish (clams, mussels), cooked	75 g (2½ oz)	0.2-0.3
Herring, cooked	75 g (2½ oz)	0.2
Sardines, canned in oil	75 g (2½ oz)	0.2
Meat Alternatives
Vegetarian meatloaf or patty, cooked	75 g (2½ oz)	0.5
Tempeh/fermented soy product, cooked	150 g (3/4 cup)	0.5
Egg, cooked	2 large	0.4-0.5
Almonds, without shell	60 mL (¼ cup)	0.3-0.4
Soy nuts	60 mL (1/4 cup)	0.2
Meatless, chicken, cooked	75 g (2½ oz)	0.2
Other
Yeast extract spread (marmite or vegemite)	30 mL (2 Tbsp)	5.3

Vitamin B2 Riboflavin absorption, metabolism and pathway

Most of the vitamin B2 in the diet is present as a combination of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) with proteins. The metabolism begins after it enters into the stomach, it is separated with the protein by the function of stomach acid and become the free Vitamin B2. It is absorbed in the upper part of the small intestine after go through the upper gastrointestinal tract. If the intake of Vitamin B2 is large, the liver and kidney often have higher concentrations, but the body’s ability to store vitamin B2 is limited. The part exceeds the renal threshold will passes through the urinary system and excrete in a free form. This is the pathway. Therefore, the daily needs of Vitamin B2 must be from the diet.

Vitamin b2 Riboflavin deficiency symptoms

Vitamin B2 deficiency is rare as this vitamin is found in almost all common foods, still it can occur in people who are under weight, those who have frequent digestive problems or in adolescent girls who avoid milk and rarely have vegetables.

Vitamin B2 (VB2), is a water-soluble vitamin but has low water solubility, is stable under acidic conditions, is unstable under alkaline conditions, and can be decomposed when exposed to light.

It is involved in the redox reaction and energy production in the body in the form of coenzymes. It is closely related to the body’s antioxidant defense system. It plays an important role in the metabolism of amino acids, fatty acids and carbohydrates. It also participates in the metabolism of vitamin B6, niacin and some drugs, and it is related to the absorption and storage of iron in the body. It is also an important nutrient for maintaining good health.

Vitamin B2 deficiency is a relatively common nutritional deficiency disease, and its performance mainly has three symptoms: lip damage, rotten mouth, hair loss, Skin lesions, loss of sleep, lip and tongue inflammation, can form a “map tongue.” Seborrheic dermatitis often occurs on both sides of the face’s nose, between the forehead and the two eyebrows, and males can develop scrotal eczema-like dermatitis.

Women occasionally have cheilitis. There are eye symptoms, the performance of blurred vision, photophobia, tears, collectively referred to as “oral reproductive syndrome.” As the deficiency coexistence with other B vitamins, the diagnosis of Vitamin B2 deficiency may not be easy. Insufficient supply of VB2 in the general diet lasts for 3-4 months and symptoms can appear. The lack of VB2 can interfere with the absorption, storage, and mobilization of iron in the body, it can result in a decrease in the content of iron in the body, and therefore anemia may occur.

The deficiency of Vitamin B2 can be diagnosed by asking patients the food eating habits and experimental treatment methods. If necessary, laboratory tests such as urinary riboflavin test can be performed, but it is generally not easy to do.

The main reasons for the Vitamin B2 deficiency are insufficient intake, ingestion of foods containing little VB2, and unreasonable storage and cooking methods, so VB2 is destroyed or lost. For example, the over-processing of rice or flour can lead to the loss of nutrients. VB2 can be destroyed during repeated heating of milk and food heating and exposure to sunlight. Deep-fried foods can destroy VB2 up to 50%. Adding alkali can cause VB2 to be destroyed in large quantities. Digestive system diseases such as long-term diarrhea, intestinal resection, and low gastric acid levels can affect the absorption of VB2.

The need of VB2 increases during the time of pregnancy, breast-feeding, heavy physical labor, high fever, etc.,. If it is not supplemented in time, it can easily lead to a deficiency of VB2. Alcoholics are also prone to VB2 deficiency due to alcohol interference in the digestion and absorption of VB2. Due to the low solubility of VB2 in water, the body’s absorption is also limited. Ingestion of VB2 in large amounts does not increase the absorption of intestinal tract indefinitely. Excessive VB2 can be excreted in the urine, so there is no report of VB2 poisoning.

VB2 is widely found in animal and plant foods. The source in animal organs, eggs, and milk are relatively high. Green leafy vegetables and legumes contain more VB2 in plant foods, and cereals have lower content.

In order to avoid VB2 deficiency, we should pay attention to eating more foods rich in VB2, correcting poor dietary habits of partial eclipses, not eating too much processed grains, paying attention to coarse grains, and improving cooking methods to reduce the loss of VB2. For pregnant women, nursing mothers, children and heavy manual workers should pay attention to increase their intake of VB2 and take certain animal foods high with VB2 every day.

Vitamin b2 riboflavin active form

The active forms (the forms in which the body uses them) of Riboflavin are synthesised in the mitochondria, forming Riboflavin 5 Phosphate which is then converted further to Flavine Adenine Dinucleotide (FAD) Metabolics Vitamin B2 is in its bioavailable form Riboflavin 5 phosphate.

Riboflavin is the essential necessity for organism in normal living as the nutriment for infant, pregnant woman nursing mother, patient after illness and the aged. It, involve , participates in the metabolishm of carbonhydrate, protein and fat, and is the major composition of flavorprotein, the transferring enzyme system of hydrogen, In clinical practice, it is applicable to perleche, glossitis, ophthalmitis, conjunctivitis, ceborrhea, scrotum inflammations with proper effect ,In food and feed industry, it is widely used as food and feed additives

Is Vitamin B2 riboflavin vegan?

Vegans care about the food they eat. They are dedicated to avoiding animal mistreatment and cruelty. For these reasons, vegans, to the best of their ability, reject eating animals or anything containing animal products, like Meat, fish, seafood, dairy, honey and eggs. However, while avoiding animal-based food, a vegan has to face with taking nutritional supplements.

As Vitamin B2 is high both in animal products also in fruit and vegetables, a vegan can eat fruit and vegetables rich with Vitamin B2.

Vitamin b2 riboflavin Function

What does riboflavin do and the function in the body

Energy metabolism – Vitamin B2 is required in its coenzyme form (FAD) for participation in the Citric Acid cycle to produce energy.
Functioning of the nervous system- Vitamin B2 is needed for the monoamine oxidase enzyme, which functions in the metabolism of neurotransmitters ( brain chemicals ) for normal functioning of the nervous system.
Maintenance of normal red blood cells- Vitamin B2 improves iron absorption and riboflavin deficiency induces anaemia , where there are immature red blood cells.
Maintenance of normal skin and mucous membranes–both acute and chronic deficiencies result in mucocutaneous lesions that disappear after adequate doses of B2 are given.
Maintenance of normal vision- Riboflavin deficiency is associated with decreased activity of the enzyme glutathione reductase, the enzyme responsible for the production of glutathione. Reduced glutathione protects the lens of the eye from oxidative damage and is decreased in cataracts. Riboflavin deficiency can cause conjunctivitis with vascularisation of the cornea and opacity of the lens (cataracts).
Metabolism of iron. Iron metabolism is impaired in riboflavin deficiency. The utilization of iron reserves from the intracellular protein ferritin requires riboflavin. Riboflavin is required for haemoglobin synthesis.
Protection of cells from oxidative stress. Vitamin B2 participates in many reactions where the cofactors P-5-P and FAD act as electron carriers, protecting the DNA, proteins and lipids from oxidative damage.
Reduction of tiredness and fatigue. As Vitamin B2 is involved in manufacturing energy adequate doses of B2 contribute to normal metabolism resulting in energy.

Benefit for headaches

Besides the above benefits, Riboflavin is also helpful for headaches.

A few studies in adults show that riboflavin (vitamin B2) might decrease frequency of migraine headaches. It has become common practice to recommend that children try riboflavin to prevent migraine; however, research on riboflavin use in children is inconclusive.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952759/

What does vitamin b2 riboflavin prevent

It can prevent following or more disease and symptoms caused by deficiency of vitamin b2 riboflavin:

Weakness
Hair loss
Skin lesions
loss of sleep
Throat swelling/soreness
Swollen tongue
Skin cracking (including cracked corners of the mouth)
Dermatitis
Anaemia
Blurred vision and itching, watering, sore, or bloodshot eyes
Eyes becoming light-sensitive and easily fatigued

Vitamin b2 riboflavin Side effects

Most people tend to tolerate riboflavin very well. You might notice your urine taking on a bright yellow color.

Too much riboflavin

Too much intake of Riboflavin may cause itching, paralysis, nosebleeds, burning sensation, tingling, etc. If you are taking anticancer drugs such as methotrexate, excessive B2 will reduce the effectiveness of these anticancer agents.

Riboflavin toxicity

Although the amounts of vitamin B2 found in multivitamin supplements and in your diet don’t pose any risks of toxicity, the therapeutic dosages could provide excessive amounts of riboflavin, according to the University of Pittsburgh Medical Center. Despite the large amounts, vitamin B2 appears to be very safe, however. Even at extremely high doses, vitamin B2 rarely causes side effects, much less toxicity, notes the University of Maryland Medical Center. Reported side effects from taking more than 10 mg per day of riboflavin include sun-induced eye damage, itching or numbing sensations, and orange-tinted urine.

Reference: https://www.livestrong.com/article/274360-vitamin-b2-toxicity/

What is Riboflavin 5′ phosphate sodium

Riboflavin 5′-Phosphate Sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes.

It is also called riboflavin 5 phosphate, RIBOFLAIVN 5’ SODIUM PHOSPHATE, VITAMIN B2 5’ PHOSPHATE SODIUM, riboflavin 5 monophosphate, riboflavin 5, vitamin b2 5 phosphate

CAS No. 130-40-5

Chemical Formula: C17H20N4NaO9P · 2H2O

Molecular weight: 514.36

Riboflavin 5′-Phosphate Sodium Property

An orange yellow crystalline powder; almost odorless and tastes slightly bitter; being wet-ejection, dissolves in water easily, but slightly in ethanol and hardly dissolves in chloroform and or in ether

Having the same actions as Vitamin B2, being better than Vitamin B2 is that is easier to dissolves in water and to be absorbed and offers a high intracorporeal usage rate. More noted medical effect comes into being while it is applied to disorder of some organic functions such as failing liver function and phosphoryl impediments out of intestinal diseases. Also it can be used as preparative for stable, highly densed and active Vitamin B2 injection, Vitamin B complex agent and eye ointment and acts as additives in food and beverage.

Riboflavin 5′-Phosphate Sodium Specification

BP/USP/EP/JP/FCC

Assay 75-80%

Application

Food and Pharma industries – use in multivitamin products

Premixes – Poultry feed premixes

As a food colour

Storage

In well Sealed Containers, Stored in Cool ,dry place and keep from light.

Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium Market

Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium manufacturers

China is the big food and feed grade Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium manufacturers and export country in the world.

Demand and supply structure: The downstream mainly consists of animal feed and food additives, which account for 64% and 32%, respectively, while pharmaceuticals and other needs are small (<5%). Feed grade VB2 powder, the assay is 80%, the food grade is mainly used as an additive in flour, energy drinks and other foods. The total demand of the global VB2 market is about 7,000 tons, and the annual demand in the domestic market is about 2,000 tons.

Manufacturing process: VB2 production process is through microbial fermentation production. At present, vitamin B2 is industrially produced by microbial fermentation in China and abroad. The microorganisms that can produce vitamin B2 are bacteria, fungi, and molds, and the industrial production mainly uses Eremotherecium ashbyii as a strain. The industrial fermentation of vitamin B2 is generally a secondary fermentation, and the fermentation liquid is first precipitated and then oxidized to separate and purify. Corn is the main raw material for the production of VB2, which accounts for more than 50% of production costs. The world’s major manufacturers include Guangji, BASF and DSM. The three companies account for more than 80% of the total capacity.

In 2016, due to the entry of new factory, the price trend was relatively sluggish. In July of 2017, manufacturers gradually entered the high-temperature maintenance period. In addition, strict inspection of environmental protection in Shandong Province, the supply of vitamin B2 contracted. During the same period, the volume of exports also began to increase significantly. The supply and demand relationship in the industry changed, prices started to rise and prices have been rising. At present (Nov, 2016), the price of vitamin B2 is about 450 yuan/kg, which is 181% higher than the 160 yuan/kg at the end of June. Follow-up With the advent of the heating season, supply may further shrink, and then superimposed on the rebound in international market exports, prices are expected to continue rising in the fourth quarter.

There are several Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Samples are available if you need it for further test.

Today’s Vitamin B2 Riboflavin price

Updated on 2018/05/26: Now the price for feed grade 80% is around RMB125/kg, the price in January was around RMB480/kg, it decreased around 75%.

Where to buy Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium?

You can buy food or feed grade Vitamin B2 Riboflavin and Riboflavin 5′ Phosphate Sodium from us, Specification complies with BP/USP/EP/JP/FCC standard.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 29 May 2018
By Marketing
In Blog Article

Vitamin B1 Thiamine Hydrochloride

What is Vitamin B1 Thiamine Hydrochloride?

Thiamine Hydrochloride, is the one form of Vitamin B1. It is composed of a pyrimidine ring and a thiazole ring, it is a water-soluble vitamin that belongs to the vitamin B family and is one of the 13 essential vitamins that the body needs.We are a experienced supplier of vitamin B1 (Thiamine Hydrochloride and Thiamine mononitrate) – Vitamin B1 is mainly found in the skin and germ of the seeds, such as rice bran and bran, which are abundant in yeast and very abundant in yeast. Lean meat, cabbage and celery are also rich in content.

The currently used vitamin B1 is chemically synthesized. In the body, vitamin B1 participates in the catabolism of sugars in the form of coenzymes and has a protective effect on the nervous system. It also promotes gastrointestinal motility and increases appetite. It is widely used in food and feed industry as a supplement.

CHEMICAL NAME: 6H-Purin-6-one, 2-amino-1, 9-dihydro-9-[(2-hydroxyethoxy) methyl]-9-[(2-Hydroxyethoxy)methyl]guanine
CAS NO.:67-03-8

MOLECULAR FORMULA: C12H17ClN4OS•HCl

MOLECULAR WEIGHT: 337.27

Properties

Thiamine Hydrochloride is a white crystalline or crystalline powder; there is a slight special odor, bitter taste, and a wet primer, easily absorbing moisture when exposed to the air. It is easy to decompose and deteriorate in alkaline solution. The pH can withstand high temperatures of 100°C at 3.5 and pH 5 is more likely to fail. The light and heat valence decreased. It should be stored in shading, cool place, should not be stored for a long time. It is stable in acidic solution, unstable in alkaline solution, easily oxidized and destroyed by heat.

Appearance: White crystals or crystalline powder

Melting point: 248 ℃

Solubility: Thiamine Hydrochloride is freely soluble in water and soluble in glycerol and slightly soluble in alcohol. ThiamineHydrochloride is used as a food additive and can be found in meat, milk, vegetables and whole grains.When exposed to air, the anhydrous product rapidly absorbs about 4% water.

Function and benefits

Participate in nutrient metabolism function

Vitamin B1 is a water-soluble vitamin essential for the maintenance of animal growth. It is mainly involved in the metabolism of sugars and some amino acids in the body. It is catalyzed by specific enzymes and can interact with ATP to form thiamine pyrophosphate (TPP). TPP is an important coenzyme for glucose metabolism. Therefore, when vitamin B1 is deficient, glucose metabolism is hindered.

On the one hand, the lack of energy supply to the nervous tissue results in the lack of multiple neuroinflammation, which can easily lead to changes in heart organ properties and changes in cardiac function; on the other hand, disturbance of glucose metabolism in the body, the production of pyruvic acid and lactic acid in blood and tissue sugar metabolism, both of which accumulate in blood, urine, and tissues can cause acidosis.

Sugar metabolism can affect lipid metabolism. If vitamin B1 is lacking and lipid synthesis is reduced, the integrity of myelin cannot be maintained, resulting in neurological lesions and multiple neuritis. Vitamin B1 deficiency can also lead to impaired cholesterol synthesis due to a decrease in 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, a key regulatory enzyme. Cholesterol is also one of the main components of cell membranes, and its synthesis barriers can affect the integrity of the nerve cell membrane.

Other functions

The lack of vitamin B1 can reduce the level of vitamin B1 in the brain and affect brain function. Adult mice were fed a diet lacking vitamin B1 for a short period of time (24 days) and were subjected to the platform-sweeping, dark-dwelling, and water-maze tests. The error rate was significantly higher than that of feeding normal diets.

Rats fed a diet lacking vitamin B1 also showed a loss of passive avoidance response and vitamin B1 recovery. The study also found that vitamin B1 has a direct neurochemical activity on the central nervous system and can interact with Ca2+ and Mg2+ to regulate the release of neurotransmitters from the presynaptic membrane.

The relationship between vitamin B1 and cardiac function is also very close. Experiments have shown that short-term lack of vitamin B1 animals, the heart muscle tension and elasticity greatly reduced, abnormal heart rate, vitamin B1 supplement can still recover. However, if there is a long-term lack of vitamin B1, severe heart damage can eventually lead to death.

Deficiency of vitamin B1 hcl in feed

As animals can not store thiamine, so Thiamine Hydrochloride can only be fed from the feed. When the animal lacks green feed for a long time and the cereal feed is insufficient, such as sow lactation, pregnancy, piglet growth and development, chronic wasting disease and fever, there is relative shortage or lack of supply. Secondary is due to the presence of substances that interfere with thiamine, such as chronic diarrhea.

Affected pigs showed poor energy at the beginning, poor appetite, slow growth or stagnation, rough coats, awkwardness, walking and shaking, ataxia, hindlimb claudication, and edema of the orbit, submandibular, hypothalamus, and hindlimb, and weakness. Bradycardia, cardiac hypertrophy; late skin mucous membranes, fever, decreased body temperature, hyperthyroidism, respiratory compulsions, and eventually died of weakness. Slow onset, duration up to 7-10 days. Piglets are clinically more than pigs.

Application and Use

Thiamine Hydrochloride is a white crystalline powder with a faint characteristic yeast/nut-like odor and a bitter taste. It is used to enhance the flavor of foods, including gravies and broths, and can be used as a functional food additive to increase vitamin B1.

What is Vitamin B1 Thiamine Hydrochloride used for?

It used to fortify foods as a supplement in food and feed. Thiamine Hydrochloride is an essential vitamin that helps prevent various health problems, including heart damage. This product is commonly used for general food fortification and dietary supplements. It can be used in solid and liquid formulations.

In food

Thiamine mononitrate is a water-soluble vitamin that is naturally found in grains, yeast, and animal organ meat. It can be used in food as a vitamin B1 source supplement.

In feed

Application in Aquatic

Due to the extensive role of vitamin B1 in aquatic animals, the chronic shortage of vitamin B1 not only affects its growth, but also causes a series of deficiencies due to metabolic reactions in the body. A stufy found that shrimps, crabs, and other crustaceans cannot synthesize vitamin B1 or have a very small amount of synthetic vitamin B1. They are difficult to satisfy their physiological needs and must be obtained through artificial feeding. A research in Chinese shrimps for promoting glucose metabolism and found that it is necessary to ensure that the vitamin B1 diet is 60 mg/kg in order to make full use of the sugar source in the diet.

In Poultry

Vitamin B1 also plays an important role in the growth of poultry. A study found that adding thiamine above 1.0 mg/kg in diets significantly increased the body weight gain of broilers at 3 weeks and 4 to 7 weeks (P<0.01). The requirements for broilers at 3 weeks of age and 4 to 7 weeks of age were 4.0 mg/kg and 1.6 mg/kg, respectively. It can therefore be demonstrated that vitamin B1 is essential in poultry feed formulations.

In Ruminants

Vitamin B1 has a special nutritional effect on ruminants. A study found that during the peak period of lactation, cows are prone to eating milk, resulting in decreased milk production. They can be injected intramuscularly with 0.25% of vitamin B130mL, and the second day after light injection, the cow begins to eat. Material, severe cases need to go back to normal after 2 or 3 doses. A study found that Wernicke’s encephalopathy is due to prolonged fasting, resulting in the onset of thiamine deficiency, mainly through vitamin B1 treatment, if diagnosed promptly, can be restored after treatment. In addition, vitamin B1 is a specific drug in the treatment of bovine ketone disease and horse myoglobinuria, and is widely used in organic phosphorus poisoning, food poisoning and drug poisoning.

Side effects

Is Thiamine Hydrochloride good for you?

As a safe food and feed additive, Thiamine Hydrochloride is generally recognized as a safe Vitamin and good for people and poultry, but there maybe some side effects:

blue colored lips;
chest pain, feeling short of breath;
black, bloody, or tarry stools; or
coughing up blood or vomit that looks like coffee grounds.

Market

Manufacturers and price

The world’s major manufacturers and suppliers of vitamin B1 (Thiamine mononitrate and Thiamine hydrochloride) include Tianxin, Huazhong, Brother and DSM, which account for 97% of globalvitamin B1 production capacity. In 2016, the global output of vitamin B1 (Thiamine mononitrate and Thiamine hydrochloride) was about 7,530 tons, and the production of China was 6,530 tons, which occupies an absolutely dominant position.

Among these manufacturers, the production capacity of the Brother was 3,200 tons, and the output is about 1400 tons, which accounts for 21% of the total China production. In 2016, the export volume of China’s vitamin B1 was about 5510 tons, and its export share had not changed much over the years. The main players in China are Tianxin, Huazhong and Brother.

In 2007, there were around 10 manufacturers of vitamin B1 (Thiamine mononitrate and Thiamine hydrochloride) in China. In the past five years, the market was stable. The only three major manufacturers in China market, Tianxin, Huazhong and Brother, accounted for 87% of the global market share.

Vitamin B1 Thiamine Hydrochloride is widely used as feed additives (37%), cosmetics (51%) and food (12%). Vitamin B1 is necessary feed, food, and pharmaceutical health products. However, it accounts for a very low proportion of production costs. Because of the increase in raw material prices, downstream manufacturers also pass through the price increase to the cost, so the downstream can tolerate its continuous price increase.

Vitamin B1 Thiamine Hydrochloride wastewater contains many thiamine compounds. Because of its high nitrogen content, it has the characteristics of high organic concentration, deep color, high turbidity, poor biodegradability, large fluctuations in water quantity and water quality, so it is a kind of industrial wastewater that is difficult to biodegrade. If a large number of discharges are not treated, it is easy to make the water black, change the odor, and there are phenomena such as water and vivid plant malformation and mutagenesis.

Environmental inspectors have pushed up environmental protection equipment and maintenance costs. As the government conducts regular inspections throughout the country, major production companies are facing the pressure of long-term sewage discharge. The three oligarchic companies generally adopt measures to limit production and reduce emissions, and prices have increased in 2017. At the end of July 2017, the price rose from 380 yuan/kg to 595 yuan/kg in recent days. The average international export price increased from 20.01 USD/kg to 26.59 USD/kg, and the export volume and export value of China manufacturers and suppliers also increased steadily.

China is the big Thiamine mononitrate manufacturers and export country in the world.

There are several Thiamine mononitrate manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Thiamine mononitrate manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Thiamine mononitrate Samples are available if you need it for further test.

Today’s price

Updated on 2018/05/26: Now the price is around RMB280/kg, the price in January was around RMB510/kg, it decreased around 45%.

Where to buy Thiamine Hydrochloride?

You can buy Thiamine Hydrochloride from us. We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

Quality Standards: Complies with USP/BP/EP/CP

STORAGE: Stored in tight, light-resistant containers. The shelf life is 36 months with the primary package.

PACKAGE: 25KG/carton or drum

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 27 May 2018
By Marketing
In Blog Article

Vitamin B1 Thiamine Mononitrate

What is Thiamine?

Thiamine, also known as thiamin or vitamin B₁. Vitamin B1 is found in many foods including yeast, cereal grains, beans, nuts, and meat. It is often used in combination with other B vitamins, and found in many vitamin B complex products. Vitamin B complexes generally include vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid.

Thiamine formula:C₁₂H₁₇N₄OS⁺

Thiamine molecular weight: 265.35 g mol⁻¹

Chemical structure:

Another name for thiamine: Vitamin B1

Thiamine solubility: Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol.

Natural sources of thiamine

Natural Food sources of thiamine include beef, liver, dried milk, nuts, oats, oranges, pork, eggs, seeds, legumes, peas and yeast.

What does thiamine do?

Thiamine, also known as vitamin B-1, is one of the B vitamins. Thiamine is a water-soluble vitamin, meaning it washes out of your body in urine, and isn’t stored in fat cells like some other vitamins. Thiamine can help your body convert carbohydrates to energy; and Thiamine can help your stomach digest foods; Thiamine can also help regulate the flow of electrolytes in and out of the cells of your nerves and muscles.

Reference: https://www.livestrong.com/article/488736-what-does-thiamine-do-for-the-body/

Vitamin B1 thiamine deficiency

Vitamin B1, which is also referred to as thiamine, is a coenzyme used by the body to metabolize food for energy and to maintain proper heart and nerve function. Thiamine is used to digest and extract energy from the foods you eat by turning nutrients into useable energy in the form of “ATP”.

A thiamine deficiency can cause weakness, chronic fatigue, heart complications, psychosis, and nerve damage.

Reference: https://draxe.com/thiamine-deficiency/

How Vitamin B1 thiamine works in your body

Maintains health of mucous membranes
Keeps normal workings of nervous system, heart, and muscles
Helps treat herpes zoster and beriberi
Supports normal growth and development
Restores deficiencies caused by alcoholism, cirrhosis, overactive thyroid, infection, breastfeeding, absorption diseases, pregnancy, prolonged diarrhea, and burns
Reduction of depression, fatigue, and motion sickness
Potential improvement in appetite and mental alertness

What is Vitamin B1 Thiamine Mononitrate?

We are a experienced supplier of vitamin B1 (Thiamine mononitrate) – which helps fight against various health problems, including heart damage. Vitamin B1 is one of the eight water-soluble B vitamins. Vitamin B1 (Thiamine mononitrate), which a vitamin found in food and used as a dietary supplement. As a supplement, it is used to treat and prevent thiamine deficiency and disorders that result from it, including beriberi, Korsakoff’s syndrome, and Korsakoff’s psychosis. Other uses include maple syrup urine disease and Leigh’s disease. It is taken by mouth or by injection. It is also widely used in feed industry as a supplement.

CAS NO.: 532-43-4

MOLECULAR FORMULA: C12H17N5O4S

MOLECULAR WEIGHT: 327.36

Thiamine Mononitrate Properties

Appearance: White or almost white crystals or crystalline powder

Melting point: 198℃

Solubility: Little soluble in water. Slightly soluble in alcohol and chloroform.

Vitamin B1 Thiamine mononitrate Function and benefits

Thiamine mononitrate can benefit following people:

Alcohol or other substance abusers by accelerating metabolism
Those with poor nutritional dietary intake
Age greater than 55 years old
Women who are breastfeeding or pregnant
Recent surgery patients
Those with liver disease, overactive thyroid, or prolonged diarrhea

Coenzyme function:
Thiamine is phosphorylated to phosphate in the cells, as a coenzyme participating in the Oxidative Decarboxylation of ketone acid and the transketolase of pentose phosphate pathway.

Other functions:
Especially useful for keeping the normal function of nerve, muscle and for the myocardium. Also maintain normal appetite, gastrointestinal peristalsis and the secretion of digestive juice.

Some illnesses may be caused by the lack of B1, like beriberi, edema, neurities, neuralgia, dyspepsia, anorexia, slow growth etc.

Difference between Thiamine mononitrate and Thiamine hydrochloride

Thiamine mononitrate and thiamine hydrochloride are two forms of Vitamin B1 manufactured by adding different groups to thiamine. They have different molar weight, physical and chemical properties depending on their chemical structures. The main difference between thiamine mononitrate and thiamine hydrochloride is that thiamine mononitrate is non-hygroscopic whereas thiamine hydrochloride is hygroscopic.

Vitamin B1 Thiamine Mononitrate

Thiamine mononitrate is a synthetic stable nitrate salt form of vitamin B1.Thiamine mononitrate is a synthetic stable nitrate salt form of vitamin B1. Thiamine mononitrate is also known as vitamin B1 nitrate and has the molecular formula C₁₂H₁₇N₅O₄S. The molar weight is 327.36 g/mol.

Thiamine mononitrate can be manufactured from thiamine hydrochloride. It is produced by removing chloride ion and mixing with nitric acid. Then, a nitrate ion combines with the thiamine molecule. Thiamine mononitrate is more stable than Thiamine hydrochloride.

Thiamine mononitrate can be used in multivitamin formulations and as a food and feed additive.

Chemical structure:

Vitamin B1 Thiamine Hydrochloride

Thiamine hydrochloride is another form of Vitamin B1 which has the chemical formula HC₁₂H₁₇ON₄SCl₂. The molar weight is about 337.263 g/mol.

Thiamine hydrochloride is the hydrochloride form of thiamine. It is a salt composed of a cation and an anion. Anion is the chloride ion. This compound is available as crystals and has a slight odor. It is soluble in water and forms a clear colorless aqueous solution. It can be used in multivitamin formulations and as a food and feed additive.

Chemical structure:

Vitamin B1 Thiamine Mononitrate Use

Is Vitamin B1 Thiamine mononitrate vegan?

Thiamine mononitrate is used as an additive to in foods such as enriched wheat or white flour. It is considered vegan as thiamine is naturally occurring in foods as a vitamin and mixed with nitric acid to become an additive.

What is Vitamin B1 Thiamine mononitrate used for?

It used to fortify foods as a supplement in food and feed. Two of the synthetic forms are known as thiamine mononitrate and thiamine hydrochloride.

Thiamine recommended daily intake

Men: 1.2 mg
Women: 1.1 mg
Pregnancy: 1.4 mg
Lactation: 1.5 mg

Vitamin B1 Thiamine mononitrate use in food

Thiamine mononitrate is a water-soluble vitamin that is naturally found in grains, yeast, and animal organ meat. It can be used in food as a vitamin B1 source supplement.

Vitamin B1 Thiamine mononitrate use in feed

Thiamine mononitrate plays a key role in helping your dog metabolize energy.

Vitamin B1 Thiamine Mononitrate Side effects

Is Thiamine mononitrate good for you?

As a safe food and feed additive, thiamine mononitrate is generally recognized as a safe Vitamin and good for people and poultry, but there maybe some side effects:

blue colored lips;
chest pain, feeling short of breath;
black, bloody, or tarry stools; or
coughing up blood or vomit that looks like coffee grounds.

Vitamin B1 Thiamine Mononitrate Market

Thiamine mononitrate manufacturers and price

Vitamin B1 is widely used as feed additives (37%), cosmetics (51%) and food (12%). Vitamin B1 is necessary feed, food, and pharmaceutical health products. However, it accounts for a very low proportion of production costs. Because of the increase in raw material prices, downstream manufacturers also pass through the price increase to the cost, so the downstream can tolerate its continuous price increase.

Vitamin B1 wastewater contains many thiamine compounds. Because of its high nitrogen content, it has the characteristics of high organic concentration, deep color, high turbidity, poor biodegradability, large fluctuations in water quantity and water quality, so it is a kind of industrial wastewater that is difficult to biodegrade. If a large number of discharges are not treated, it is easy to make the water black, change the odor, and there are phenomena such as water and vivid plant malformation and mutagenesis.

China is the big Thiamine mononitrate manufacturers and export country in the world.

Today’s Thiamine mononitrate price

Updated on 2018/05/26: Now the price is around RMB280/kg, the price in January was around RMB510/kg, it decreased around 45%.

Where to buy Thiamine mononitrate?

You can buy Thiamine mononitrate from us. We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

Usage: Used for feed additive, food additive and pharmaceutical material.

Quality Standards: Complies with USP/BP/EP/CP

STORAGE: Stored in tight, light-resistant containers. The shelf life is 36 months with the primary package.

PACKAGE: 25KG/carton or drum

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 26 May 2018
By Marketing
In Blog Article

Inositol

What is Inositol?

Inositol was called vitamin B8, but since our body is able to produce a certain amount of inositol by itself, it is no longer classified as vitamin B8. Inositol, commonly known as cyclohexanol, is widely found in a variety of natural animal, plant, and microbial tissues. As it was originally extracted from muscle tissue, it is known as inositol, also known as muscle sugar.

Synonyms：Meso-imositol, myo-inositol, 1,2,3,4,5,6-hexahydroxycyclohexane

ChemicalFormula：C6H12O6

Specification：NF/FCC/USP/EP

Chemical structure:

Inositol is found in most foods like, high in wholes grains and citrus. Myo-inositol is the specific stereoisomer from nine Inositol stereoisomers that is commonly used in food and feed products, such as in dietary supplements, energy drinks, and infant nutrition.

Inositol is a safe supplement but high doses may cause mild gastrointestinal distress.

Is inositol a vitamin?

Inositol was called vitamin B8 before, is not officially recognized as a vitamin, because it can be synthesized from glucose by the bacteria within our intestines.

Difference between myo inositol and inositol?

Inositol usually refers to Myo-inositol, the official name is Myo-inositol.

Foods high in inositol

Studies indicate the largest amount of myo-inositol is found in fresh fruits and vegetables
Inositol is also found in meat sources and eggs. While meat sources are rich in inositol, it is important to consume only those sources which are grass fed and chemical free sources. If the meat sources are raised on steroids and antibiotics, they can do more harm than good.
Fruit sources of inositol include oranges, peaches, and pears. Potassium-rich fruits like banana are also considered as foods high in inositol.
Grains are among the foods high in inositol. Note that inositol occurs in whole grains and not processed, refined grains.
Legumes and sprouts are also considered as foods high in inositol. Vegetables, such as bell peppers, tomatoes, potatoes, and asparagus, along with green leafy vegetables, are also good sources of Inositol.
Nuts and seeds also contain a good amount of inositol.

Reference: https://www.sepalika.com/living-well/foods-high-in-inositol/

Inositol Properties

Inositol molecular formula C6H12O6, a white crystalline powder, molecular mass 180.16, density 1.752, melting point 225-227°C. It is odorless and slightly sweet. Its sweetness is half that of sucrose. It is relatively stable in the air, easily absorbs moisture, and its aqueous solution is neutral. Inositol is easily soluble in water, slightly soluble in alcohol, glacial acetic acid, glycerol and ethylene glycol, and insoluble in organic solvents such as ether, chloroform and anhydrous acetone. At temperatures lower than 50°C, dihydrates of colorless monoclinic crystals can be crystallized from water, and can be dehydrated to an anhydride at 100 to 110°C.

Inositol is a member of the vitamin B family, and is a lipophilic vitamin like choline; inositol and choline combine to form lecithin; the unit of measurement is mg (mg); Application: For the preparation of multivitamin pills and various nutritive amino acid-vitamin infusion products. In addition, it can also be used for the treatment of liver cirrhosis, hepatitis, fatty liver, arteriosclerosis, hypercholesterolemia, hyperglycemia, and carbon tetrachloride poisoning, as well as for the synthesis of nicotinic acid inositol esters, pulse and other drugs.

At the same time it can also be used directly as drugs, such as inositol tablets, liver alcohol. Inositol also has the effect of preventing skin aging and hair loss and promoting the growth of various species and yeasts, and is used as a food additive. The use of inositol in the human body can reduce cholesterol and promote the growth of healthy hair; also can prevent hair loss and eczema; to help redistribution of fat in the body (redistribution); have a sedative effect.

Inositol and biflavin are combined together to make yolk. Inositol plays an important role in the supply of brain cell nutrition. It helps to prevent arteriosclerosis by metabolizing fat and cholesterol and lowering cholesterol. It can also remove liver fat, promote the growth of healthy hair, prevent hair loss, prevent eczema deficiency eczema, and makes hair whiter. The use of inositol in foods: Inositol is a “bioactive hormone” involved in metabolic activity in the body. Inositol has many functions such as immunization, prevention and treatment of certain diseases, and can be used in the fermentation and food industry. The growth of many species of bacteria and the promotion of yeast growth, etc., if the lack of inositol in animals, there will be growth stagnation and hair loss and other phenomena, the daily demand for inositol in humans is l-2g, many health drinks and children’s food All have added inositol.

Inositol Function and benefits

Similar to the effect of vitamin, increased energy, lower cholesterol, prevent eczema, natural tranquilizer, promoting hair growth.

Inositol – In this case, inositol is an essential nutrient source for birds and mammals. For example, mice can cause hair loss and rats can cause symptoms such as abnormalities around the eyes due to lack of inositol. Rats can metabolize inositol in large amounts, but not much in the urine. Sharks seem to be able to convert inositol into a substance that stores energy. It is one of the ingredients of Lifeline I. Inositol is a water-soluble vitamin; one of the vitamin B family, inositol and choline are also fat-like vitamins, also known as cyclohexanol can promote cell metabolism, promote development, increase appetite For the treatment of hyperlipidemia, cirrhosis.

Inositol can lower cholesterol, promote healthy hair growth, prevent hair loss, eczema, liver fat metabolism, and help weight loss, it has a calming effect.
Inositol can be used as feed additive for fish, shrimp and Livestock ,it can promote the rapid growth of fish, enhance immunity, and achieve a high and stable yield. In the recent years, through demonstration experiments, it proves that inositol is the essential feed additives in aquaculture .
Inositol is the premise of the synthesis of many biological molecules, it can be used for the synthesis of galactose inositol, and so on.

Inositol Manufacturing process

The raw material for manufacturing inositol is Phytin. Phytin is widely found in the seeds of plants. The commonly extraction method is using diluted acid extraction and then alkali neutralization precipitation. That is to say, soaking raw materials with dilute inorganic acid, and then using calcium hydroxide – alkali. The neutral solution precipitates in the solution to obtain a pasted Phytin product. Due to the different raw materials used, the manufacturing process is slightly different.

Inositol from rice bran

The extraction of phytin from rice bran is currently a major method. Domestically, defatted rice bran is usually used as a raw material, soaked in 8 to 9 times the 0.1% hydrochloric acid of rice bran for 6 to 8 hours. The soaking solution is discharged, and lime milk is used as a precipitant to adjust the pH. A PH value about 5.8 to 6.0 can be used to make the precipitation of Phytin. When the rice bran is leached with acid, neutral salts such as urea, ammonium sulfate, ammonium bicarbonate, Glauber’s salt, and salt are added to prevent the dissolution of hydrocarbons, proteins, and oils and fats, and the amount thereof is 0.5% to 5% of the leach liquor.

Inositol from wheat bran

Phytin can also be extracted from wheat bran. Compared with rice bran, wheat bran contains a large amount of starch and is directly fed into the production of Phytin. The yield is only 3% to 4%. If the starch is prepared by rough grinding or sieving to remove the starch, then the yield can reach about 8%. Crude starch is sold and its value is higher than that of wheat bran. This process is economically more cost-effective.

The manufacturing process for extracting phytin from wheat bran is as follows: wheat bran → rough grinding or sieving → acid leaching → neutralization sedimentation → filtration → washing →pasted Phytin.

Inositol from Corn or Corn soaking water

The corn grain contains 1.31% of Phytin. During the production process of the corn starch factory, a large amount of sulfite corn soaking solution is produced, which contains 0.5% to 1.0% of phytin, which was treated as waste water to discharge and pollute the environment. Using corn steep liquor manufactures Phytin is usually prepared by a single precipitation of lime. Soak the solution for 3 to 4 days to remove impurities, filter out the clear liquid, and under constant stirring, neutralize with 10% lime, mix thoroughly, adjust the pH value to 5.8, and let stand for 2 hours to make the phytin full. Precipitation precipitated. Extracting phytin from corn soaked waste water is more economical than rice bran and wheat bran.

Phytin can also be extracted from corn or legume starch. For example, rice bran cake, the content of phytin is around 8%, extraction rate can be 80%, production capacity of Phytin can be around 52kg/ton.

Pressurized hydrolysis method is the traditional method of inositol production. The pasted Phytin and water are pulped into a pressure hydrolysis cooker at a ratio of 1:3 to 3:5. The reaction is stirred at a hydrolysis pressure of 0.5 to 0.6 MPa. 10h, when the pH is about 3 ~ 3.5, the hydrolysis is complete.

In the hydrolysis process, fresh lime is added in portions to neutralize; the controlled pH value to 3 – 3.5, the byproduct calcium phosphate can be directly used as phosphate fertilizer or processed into feed additive phosphate. Then add activated carbon fiber to the above neutralization solution with a solution amount of 0.5% to 1.5%, and after decoloration by boiling for 20 minutes, inositol was filtered while hot. The filtered serum is sent to vacuum concentration, concentrated to a relative density of 1.28 to 1.30, cooled and crystallized, centrifuged, and the isolated crude inositol is sent for purification, and the the liquor is used to recover inositol therein.

The crude inositol was added to distilled water at a ratio of 1:1.2 to 1.5, heated and dissolved, and put pharma grade activated carbon, the quantity is about 1.5% to 2.0% of crude inositol. After decoloration by boiling, the solution was filtered by suction and the filtrate was cooled to 32°C. Left and right, filtration and crystallization, and finally the crystals are washed with a small amount of anhydrous ethanol to obtain inositol as a wet product. The mother liquor separated during the refining process is concentrated and sent to a purification process to minimize the loss of inositol. The wet inositol is dried at 66 to 70°C to obtain a finished product.

The hydrolysis process is a key step in the manufacturing of inositol. The complete degree of hydrolysis determines the inositol yield. Low temperature and low pressure hydrolysis process yield up to 2% to 3%, currently the method widely used among domestic and abroad manufacturers is the pressure hydrolysis process, the working pressure is mostly 0.3 ~ 0.8MPa, foreign is 1.5 ~ 2.5MPa. Increasing the reaction pressure will shorten the hydrolysis cycle and increase the product yield. The key factors of the hydrolysis reaction are the pH, reaction temperature and operating pressure of the hydrolysis slurry. The pH of the hydrolysis slurry is 4.5, the hydrolysis temperature is 170-180°C, and the pressure is 0.7-0.8 MPa. The hydrolysis is carried out for 8-9 hours. The rate can reach more than 95%.

Many China manufacturers use calcium carbonate in the hydrolysis process. Addition of inositol into the additives can increase the hydrolysis rate, reduce the inositol loss, and help improve the product quality. The added amount is generally about 5%. The addition of calcium carbonate can reduce the soluble phosphoric acid and phosphate in the hydrolyzate, generate more insoluble phosphate, accelerate the hydrolysis rate, facilitate the hydrolysis, reduce the burden of neutralization and salt removal, and add calcium carbonate to the pH of the hydrolyzate. A value above 5 reduces the corrosion of the hydrolysate to the equipment, but a large amount of carbon dioxide is generated at a certain stage during the hydrolysis process to increase the pressure rapidly, and the hydrolysis tank needs to be equipped with an explosion-proof device.

Phytin is hydrolyzed to inositol, insoluble calcium phosphate, and soluble calcium dihydrogen phosphate, calcium hydrogen phosphate and a small amount of phosphoric acid. In order to separate inositol, neutralization precipitation is required. In the traditional process, the precipitant is the oxides of alkaline earth metal and hydroxides are used alone, and it is difficult to grasp many factors such as the concentration of the precipitant, the way of adding, the control of the pH value and the determination of the neutralization end point. The use of a composite precipitant to neutralize the salt can avoid the formation of inositol complexes, make the reaction stable, the pH value can be better controlled, and the loss of inositol during salt removal can be reduced.

The purpose of the purification is to remove the ions and pigment impurities in the crude inositol. Domestic manufacturers generally use reagents for impurity removal, which has the advantages of simple operation and low cost.

The specific operation is: at 80-90°C, the activated carbon fiber is added for decoloration to colorless and transparent. After decoloration, Ba(OH)2 and oxalic acid are added under the condition of pH 7.0 to 8.0, and a small amount of Ba(OH)2 is added first. After a few minutes, a small amount of oxalic acid is added to strictly control the pH to 7.0 to 8.0. Other impurities, activated carbon and oxalic acid need to be pre-treated. In order to further increase the purity to meet the requirements of the pharmacopoeia, it must be further refined and treated as described above.

The commonly used impurity removal method in foreign countries is the ion exchange resin method, which removes cations through cation exchange resin columns, and then removes acid ions and other ions through anion exchange resin columns. After such treatment, the quality and yield of inositol will be greatly improved. , And a crystallization that is pure inositol. The use of ion-exchange resins can reduce product losses, which can increase 2% to 4% over conventional methods. Impurity ion removal is complete, inositol finished product quality is good, and it is not necessary to use ammonium oxalate, barium hydroxide, activated carbon and other raw materials, shorten the process flow, processing capacity, suitable for inositol mass production, but the resin regeneration costs higher

From the raw material corn – corn soaking water – phytin – Inositol ,we have the complete production chain and use our factory’s own corn soaking water to extract the phytin ,this will make our Inositol ‘s quality more stable.

From corn soaking water, all the material through the stainless steel pipeline airtight transportation, the intermediate products Phytin directly transport to the inositol workshop, which will greatly shorten the cycle ,avoid the loss of the intermediate links and reduce the transportation costs. Fuli factory have a good layout and functional, systematic workshop design, production control automation, and continuous production process.

Inositol Use & Application

Inositol can be used in functional beverage, dietary supplements, infant milk powder, medicine, health products, aquatic feed additives (fish, shrimp, crab, etc.), personal care products, senior pet supplies.

Used in Poultry feed/Animal feed

Inositol acts as a bioaccelerating agent in the feed industry and is used in high quality Poultry feed/Animal feed to increase the contraction of the digestive tract, promote gastric motility, and promote the digestion and absorption of food. Lack of inositol in higher animals can cause growth arrest, hair loss, dermatitis, slow digestion and absorption of food, and disturbance of physiological activity in the body.

Inositol has a multi-vitamin function, which can regulate the metabolism of dairy cows, promote the synthesis and secretion of milk, and help to improve the digestion, absorption and utilization of nutrients in Poultry feed/Animal feed. Its taste is slightly sweet and can improve feed palatability, so it can Improve milk intake and milk production.

Inositol can increase milk fat, milk protein, lactose content.

In the United States, in order for dogs to grow healthily and reduce disease, proper amount of inositol is added to the dog food, and inositol is added to the diet in an amount of 2 to 4 mg/10 kg body weight.

Myo-inositol can promote the growth of the skin of the moss, making it glossy and bright. Under normal circumstances, the inositol dosage 2~4mg/10kg body weight is added to the diet. Hydra skin abscission is a disease caused by a lack of vitamin inositol in the diet that causes metabolic disorders. The diseased hairs and hairs fell into pieces and the light part of the hair was removed, and the entire body was exposed. If it occurs in the breeding season, it affects normal reproduction. In the season of skin removal, it seriously affects the quality of the skin. If not treated, it will also cause death. The inositol inositol supplementation was increased 5 times and used with vitamin B2. According to actual experience, the dosage of inositol 10 to 20 mg/10 kg body weight was added to each leeches diet.

Practice has proved that adding proper amount of inositol to the feed can promote the growth of livestock and prevent death. The amount added in the diet is generally 0.2~0.5g.

Used in aquaculture

At present, many large feed companies in China and abroad have used inositol as a nutritional additive to aquatic feed. In aquaculture, inositol as a vitamin is added to the feed to increase feed efficiency, accelerate fish growth, promote fat metabolism in the liver and other tissues, and increase growth rates by more than 10%.

Inositol in fish farming applications

Inositol, an indispensable nutrient for fish, is an indispensable low molecular organic matter for aquatic animals, especially aquatic animals with high economic value, and plays an important role in maintaining its normal physiological functions. After inositol is absorbed by fish, it is present in the liver and serum, and can increase the activity of cholinesterase, thus contributing to starch digestion and body weight gain in vivo. When inositol intake is insufficient, fish growth, anemia, fin rot, and feed conversion rate are low.

Inositol in crustaceans

Studies have shown that inositol as a growth promoter significantly increases the growth of shrimps and river crabs.

The lack of inositol can cause a variety of illnesses

Many studies have shown that the lack of inositol in animals, especially in aquatic animals, can cause great harm to normal growth. The lack of inositol in rainbow trout causes anorexia and digestive effects to slow down, hepatic triglycerides increase, and the total phospholipid mass decreases. The lack of inositol in carp causes skin damage, lesions, and slow growth. Japanese quail lacks inositol in the grayish bowel, low appetite, and production stagnation.

Inositol promotes the growth rate and survival rate of parrot fish, squid, and gums in Japan. In the absence of fish, fins are eroded, growth is poor, and mortality rate is increased.

Using proper amount of inositol to the feed can increase the utilization of feed fat in grass carp juveniles and increase feed value.

Using inositol during goldfish culture can significantly increase the swimming ability of goldfish.

Recommended Dosage in aquaculture

The dosage of Inositol used in aquatic products based on years of research and practical experience, the amount of inositol added to feeds of different types of aquatic products is as follows:

Application and use	name	Inositol dosage mg/kg
Fish	grass carp	166-214
	Squid and frogfish	1000
	Squid and mackerel	150
	Tilapia	350
	Cobia	200
	eel	500
Crustacean	prawn	4000
	Shrimp	2000
	Chinese mitten crab	400

Used in food

Application in the field of food additives Inositol is one of the vitamin B family and is also widely used as a food additive in vitamin functional/energy beverages, baby milk powder, health food products and pharmaceuticals.

Inositol Side effects

Is inositol safe?

Although Inositol is considered safe, there may be some possible side effects such as nausea, stomach pain, tiredness, headache, and dizziness.

Can inositol cause anxiety?

It is helpful anxiety.

Myo-inositol is safe for pregnancy and breastfeeding?

Pregnant and breastfeeding mothers are not advised to consume inositol though there is no research that shows the side effects.

Inositol Market

Global market demand and trend

The application field of Inositol is gradually expanding and the market demand continues to increase. Inositol is used for a wide range of purposes. It has the effects of metabolizing fat and cholesterol and is used to treat hepatitis, cirrhosis, fatty liver and high cholesterol in the blood. It also promotes healthy hair growth, prevents hair loss, prevents eczema, and helps redistribution of body fat; in addition, inositol also plays an important role in the supply of brain cell nutrition. Inositol is also a “bioactive element” involved in the body’s metabolic activities, with many functions such as immunity, prevention and treatment of certain diseases.

In recent years, people have found that inositol has many new uses, and its application field is constantly expanding. Such as: chemical synthesis of paclitaxel, its cancer treatment effect is poor, but if modify inositol, the effect in cure cancer will be better than natural products, which has become the new consumption point of inositol in the pharmaceutical industry today. Fluorositol is a new product that has been developed in recent years and has anti-cancer and high-level immune functions. Inositol deep processing can be made inositol methyl ether, inositol peptides and other products, in the pharmaceutical, chemical and other industries have great practical value. In addition, people have also found that inositol and sarcoma alkaloids can convert fat into heat energy. As a result, inositol-containing fat-reducing body-building foods and nutritional products containing inositol have become popular in Europe and the United States, and future demand will continue to increase.

With the accelerated civilization of the population and the improvement of living standards, people’s demand for health foods continues to increase. The high nutritional value of fish meat just satisfies this requirement. According to authoritative data, in recent years, due to changes in consumer demand and aquaculture structure, the average annual growth rate of aquatic feed production in China has been as high as 17%, and the proportion of pig feed and poultry feed has been declining. The aquatic feed industry has become the biggest bright spot in the development of the feed industry, and it has become the industry with the fastest development, the best benefits, and the greatest potential in the feed industry in China. Inositol as a vitamin additive for aquafeeds will increase in use year by year. On the other hand, with the gradual popularization of vitamin functional/energy beverages, the use of inositol is gradually increasing.

Inositol manufacturers

Inositol is an essential vitamin needed for protein, carbohydrate and fat metabolism. China production occupies the large part in the world.

China is the big food and feed grade Inositol manufacturers and export country in the world.

In 2000, China’s inositol export volume was 1400 tons; in 2004, the export volume reached 2,000 tons; in 2006, the export volume was 2,400 tons; in 2009, the export volume reached 2,600 tons. In recent years, due to the strong demand for inositol in the global market, China’s exports have increased rapidly. In 2010, the export volume exceeded the 3,000-ton mark to reach 3,300 tons; in 2013, the export volume was 3,600 tons; in 2014, the export volume exceeded the 4,000-ton mark, which was 4,200 tons; in 2015, the export volume reached 4,450 tons, and the export amount It was US$ 35.86 million. In 2016, China’s inositol export volume was 4,836 tons, an increase of 8.67% year-on-year, a record high, and the export amount was US$30.79 million, a decrease of 14.1% year-on-year.

The export prices of myo-inositol have fluctuated up and down in the past ten years, and the magnitude is relatively large. The main export destinations are Asia, Europe and North America. Inositol exported to these three regions accounts for 90% of total exports. The United States, Europe, and other developed countries are the main destinations for inositol exports in China, of which inositol exports to the United States account for about 20% of China’s total exports.

There are several Inositol manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Inositol manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Samples are available if you need it for further test.

Where to buy Inositol?

You can buy food or feed grade Inositol from us. Our inositol originates from a specially selected non-GMO species of corn, specification complies with NF/FCC/USP/EP standard.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 21 May 2018
By Marketing
In Blog Article

Food and Feed Grade Vitamin B3: Niacinamide

What is Niacinamide?

Niacinamide is a water soluble Vitamin, also known as Vitamin B 3. Another form of Vitamin B3 is Niacin. Niacinamide is a necessary for human and animals metabolism and making energy. Niacinamide helps to prevent and control diabetes, maintains normal functioning of skin, nerves, digestive system.

Niacinamide properties

Chemical name: 3-Pyridinecarboxyamide
CAS No.: 98-92-0

Chemical structure:

Molecular Formula: C6H6N2O

Molecular Weight: 122.13

Appearance: White crystalline powder or white granular powder

Melting point: 128~131℃

Solubility: 1g Niacinamide can dissolve in 2ml of water, 1.5 ml of ethanol and about 10ml glycerol. Soluble in acetone, amyl alcohol, chloroform, propylene glycol, butanol. Practically insoluble in ether and benzene.

Niacinamide Function

Nicotinamide is an important part of the coenzyme Ⅰ and coenzyme Ⅱ in human and animal body, involved in lipid metabolism, tissue respiration and carbohydrate oxidation during the process of anaerobic decomposition. It’s mainly used for medicine, food and feed additives field.

Function in animal feed additives, Nicotinamide can prevent from skin lesions and digestive diseases; promote animal growth, improve egg production and hatching rate, to ensure good feather growth; to treat of mucosal inflammation and ulceration; Prevent from the livestock and poultry perosis.

Function in medicine and food additives, Nicotinamide can prevent of skin lesions and digestive diseases; to promote participation in the body of material and energy metabolism, to promote human growth and development; to treat a variety of mucosal inflammation and ulcers with other drugs; Strong vasodilator effect, to improve the blood supply to the body function, feature favorable effect on cerebral thrombosis, coronary heart disease, hyperlipidemia and so on; to treat nicotinic acid , nicotinamide deficiency caused by its long-term medicament of isonicotinic acid hydrazine and analogs.

Niacinamide Benefits

The European Food Safety Authority (EFSA) has confirmed following health benefits for the dietary intake of Niacinamide:

Normal energy metabolism and nutrient utilization
Normal function of the nervous system and mental function
Maintenance of normal skin and mucous membranes
Maintenance of normal bones, teeth, hair and nails

Niacinamide are used interchangeably in most of the applications in Animal Nutrition.

Human Nutrition

Essential vitamin for body growth and maintenance
Prevents bone abnormality
Reduction of ketosis incidence
Improves milk production

Skin care

Improves skin barrier function and helps in skin moisturization
Helps in skin lightening- reduces red blotchiness, yellowing and hyper pigmented spots
Tackles anti-aging, reduces wrinkling and Improves skin texture
Reduces acne and sebum production, inhibits oiliness and greasiness of skin.
Repairs photo damaged skin and reduces damaging effects of UV on skin

Hair and Scalp care

Helps in hair growth

Under-Eye Care

Softens the rings around the eyes

Recommended Dosage: 10~200mg/kg

Storage: Store in original unopened cartons，to be protected from heat and light，keep away from moisture. Expiry 36 months from the date of production in original sealed packages. Once the original packages are opened, please use the goods within a short period.

Packaging: 25kg net in carton with Aluminum foil bag or 1000kg woven bag

Difference between Niacin and Niacinamide?

Niacinamide is not the same as niacin. Niacinamide is also known as nicotinamide or nicotinic acid amide. It is the amide of niacin. Niacianamide is part of B-vitamin and it is water soluble. Niacinamide is derived from niacin. These two are components of B3-vitamin and they are often used as supplements interchangeably.

Vitamin C (Ascorbic Acid) and Niacinamide can be used together?

Research has shown that combining niacinamide and vitamin C does not lead to skin problems; in fact, the combination can lead to a wealth of skin benefits.

Niacinamide is a pretty “tough” ingredient; light and air don’t have the same effect on it as they do on antioxidants like vitamin C. What’s important for niacinamide is that the product be formulated at a pH that’s close to neutral. Vitamin C (pure ascorbic acid), on the other hand, does best in a low-pH (acidic) environment. However, nicotinic acid—the undesirable by-product of niacinamide and vitamin C—becomes an issue only when the niacinamide and vitamin C are combined in a high-temperature environment for a long time. That temperature is higher than you’d find in most at-home scenarios, including leaving a box of skincare products sitting outside in the sun for a couple of days.

Also, it’s important to point out that this concern applies only to pure vitamin C, not to its many other forms (such as magnesium ascorbyl phosphate, tetrahexyldecyl ascorbate, and ascorbyl glucoside). So, to reiterate, combining ascorbic or l-ascorbic acid with niacinamide is fine.

In short, any studies that show a definite issue from combining niacinamide and vitamin C were conducted in an environment that does not reflect what average skincare products experience during development, manufacturing, or in real-world storage and usage.

Reference: https://www.paulaschoice.com/expert-advice/skincare-advice/myths/can-niacinamide-and-vitamin-c-be-used-together.html

Niacinamide food sources

Niacin and Niacinamide are forms of Vitamin B3. Vitamin B3 is found in many foods including yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains.

Niacinamide Uses

Niacinamide is used as a food supplement to ensure replenishment of nutrients in human nutrition, animal nutrition and cosmetics.

Human Nutrition: In Vitamin premix, dietary food supplements, enrichment of breakfast cereals and flour, beverages & energy drinks, infant formulas, baking and confectionery.
Pharmaceuticals: Multivitamin tablets, Niacinamide for treatment of diabetes and Niacin for high cholesterol levels.
Animal Nutrition: Poultry, dairy, swine, cattle, pet food, veterinary drugs
and aqua feed.
Cosmetics: Skin creams, hair lotions and other personal care

Most Vitamin B3 Niacinamide deficient animals show poor growth and reduced efficiency of feed utilization.

Vitamin B3 Niacinamide deficient chickens show inflammation of the upper gastrointestinal tract, dermatitis of the legs, reduced feather growth and pecrosis.

Ducks and Pigs are particularly sensitive to Vitamin B3 deficiency. Ducks show severely bowed and weakened legs and diarrhoea while Pigs show diarrhoea, anaemia and degenerative changes in the intestinal mucosa and nervous tissue.

Studies have shown Niacinamide treatment of lactating cows to depress circulating ketones and hence concentrations of non-esterified fatty acids in the plasma.

Vitamin B3 Niacinamide deficient dogs show necrotic degeneration of the tongue with changes of the buccal mucosa and severe diarrhoea.

The Animal feed and Nutrition industry typically supplements diets with Vitamin B3 Niacinamide to ensure that the daily requirement of the vitamins is met.

Recommended Vitamin B3 Niacinamide Dosage per Kg of complete feed.

PoultryApprox 30-50 gm/ Ton of Feed
SwineApprox 15-50 gm/ Ton of Feed
Cattle (calves, milk replacer)Approx 30-40 gm/ Ton of Feed

Niacinamide is preferred form of Vitamin B3 to be used in personal care application. It has shown encouraging results when formulated into skin creams, hair lotions and other personal care products.

The ingredient when incorporated in the topical delivery system enhance elegance, skin feel and texture upon application.

While research is ongoing to discover additional properties of Niacinamide, many clinical studies have already concluded following beneficial properties of Niacinamide.

Niacinamide Side effects

Although niacinamide is considered as a safe vitamin, there are some side effects.

Unlike niacin, niacinamide does not cause flushing. However, niacinamide might cause minor adverse effects such as stomach upset, intestinal gas, dizziness, rash, itching, and other problems. When applied on the skin, niacinamide cream might cause mild burning, itching, or redness.

Reference: https://www.webmd.com/vitamins/ai/ingredientmono-1534/niacinamide

Niacinamide Market

Niacin VS Niacinamide in the market

Nicotinic acid and niacinamide are both known as VB3. Since niacin and niacinamide have the same physiological functions, both have equivalent biological titers and the same activity measurement, niacin and niacinamide are all supplemental forms of animal VB3. .

Due to the different distribution of nicotinic acid and nicotinamide production plants in different countries and regions, as well as the promotion and guidance of manufacturers, nicotinic acid is basically selected in Europe and the United States. In China and Southeast Asia, formulators are more often used to choose nicotinamide.

Before 2011, no domestic company had a real production capacity of 500 tons of niacin, and the annual production of nicotinamide in China was about 10,000 tons. Therefore, the price of niacin in the market is generally higher than that of niacinamide by about RMB 2,000 per ton. Based on price and promotion guidance, the Chinese market basically uses nicotinamide.

Today, the rapid development of nicotinic acid manufacturers in China, and the price of niacin is approximately 1,000 yuan less than that of nicotinamide. The use of niacin has a cost advantage over nicotinamide.

Previously, we thought that niacin had a certain degree of irritation and inconvenience. Nowadays, the nicotinic acid produced as crystal granular process has basically eliminated the pungency of niacin;

And with the widespread adoption of automated production lines, opportunities for workers and materials have been greatly reduced.

We are accustomed to think that niacin is less stable than niacinamide.

Experiments show that nicotinic acid and nicotinamide are both stable and maintain a high survival rate in the composite multidimensional and premixed materials;

Experiments showed that there was no difference in the effects of nicotinic acid and nicotinamide on trace elements, vitamins and other active ingredients.

Tests have shown that granular nicotinic acid is superior to niacinamide.

Tests have shown that nicotinic acid is less hygroscopic than niacinamide, and it is not easy to absorb moisture and agglomerate, making it more stable and long-term storage. When the niacin package is in good condition, store it at room temperature for 3 years, and the main points and indicators meet the standards.

Niacinamide manufacturers

Niacinamide has the identical vitamin function as niacin without the vasodialating effect that can cause skin flushing, making this Vitamin B3 form a suitable ingredient for oral and topical human applications. Manufacturers of energy beverages and dietary supplements include niacinamide in formulations to aid metabolism of protein, sugar and fat for energy conversion. Niacinamide is also used in a variety of cosmetic, skin care, and hair care products for anti-inflammatory, lightening and brightening, and conditioning benefits. Commercially available facial moisturizers, eye creams, anti-aging products for the face and body, hair shampoos, conditioners, and coloring treatments include Niacinamide as an ingredient.

Vitamin B3 Niacinamide supplementation for animal nutrition produces a more complete diet that improves growth and feed efficiency and overall health. Vitamin B3 Niacinamide activity is essential for healthy animal metabolism and supplementation adds value to your feed program with proven results.

China is the big food and feed grade Niacinamide manufacturers and export country in the world.

There are several Niacinamide manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Niacinamide manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Niacinamide Samples are available if you need it for further test.

Where to buy Food and Feed grade Niacinamide?

You can buy food or feed grade Niacinamide from us. We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 20 May 2018
By Marketing
In Blog Article

Food and Feed Grade Vitamin B3: Niacin or Nicotinic acid

What is Niacin?

Niacin is a water soluble Vitamin b3. Another form of Vitamin B3 is Nicotinamide. Niacin is a pyridine carboxylic acid, also known as Nicotinic acid, Vitamin B3, Vitamin PP, 3-Pyridinecarboxylic acid, widely used as food and feed additive, also used as vasodilator. Niacin is essential to human life and the deficiency can result in a wide variety of side effects.

Niacin is an immediate precursor of NAD and NADP which plays an important role in animal energy utilization, synthesis and catabolism of fats, proteins and carbohydrates.

Niacin or Nicotinic acid Properties

Molecular Formula: C6H5NO2

Appearance: white crystaline powder or granular, free flowing, sparingly soluble. It is seldom affected by acids, bases,oxygen, heavy metal ions, light and heat.

Molecular Weight：M-123.11

Chemical structure:

Is Niacin or Nicotinic acid water soluble?

It is soluble in water. Solubility 18 g L−1

Where does Niacin or Nicotinic acid comes from?

Niacin is found in a variety of whole and processed foods, including fortified packaged foods, meat from various animal sources, seafood and spices.

Difference between Niacin and Nicotinic acid?

Niacin and Nicotinic acid are same. Another name for niacin: Nicotinic acid, Pyridine-3-carboxylic acid

Niacin or Nicotinic acid Function

Niacin or Nicotinic acid is converted to niacinamide in the human body, involved in lipid metabolism, oxidation in tissue respiration and anaerobic decomposition for carbohydrate oxidation. It’s mainly used in medicine, food and feed additives field.

In animal feed additives, its main functions are: to prevent skin lesions and digestive diseases; to promote animal growth, improve egg production and hatching rate, to ensure feather growth; to treat mucosal inflammation and ulceration; Prevent the livestock and poultry from perosis.

In medicine and food additives, and its main functions are: to prevent of skin lesions and digestive diseases; to promote participation in the body of material and energy metabolism, to promote human growth and development; to treat a variety of mucosal inflammation and ulcers with other drugs; Strong vasodilator effect, to improve the blood supply to the body function, feature favorable effect on cerebral thrombosis, coronary heart disease, hyperlipidemia and so on; to treat nicotinic acid, nicotinamide deficiency caused by its long-term medicament of isonicotinic acid hydrazine and analogs. As a pharmaceutical intermediate, Nicotinic acid is used for production of isoniazid, niacinamide, nikethamide and inositol nicotinate.

How does Niacin or Nicotinic acid work?

Niacin is absorbed by the body when dissolved in water and taken by mouth. It is converted to niacinamide if taken in amounts greater than what is needed by the body.

Niacin is required for the proper function of fats and sugars in the body and to maintain healthy cells. At high doses, niacin might help people with heart disease because of its beneficial effects on clotting. It may also improve levels of a certain type of fat called triglycerides in the blood.

Deficiency of Niacin or Nicotinic acid in the body

Long term niacin deficiency results in a disease called “pellagra.” Niacin is involved in DNA repair as well, so a shortage of this vitamin is not something you want. Low dietary amounts of niacin have even been associated with various forms of cancer.

The most common symptoms of niacin deficiency involve the skin, the digestive system, and the nervous system. The symptoms of pellagra are commonly referred to as the three “Ds”: sun-sensitive dermatitis, diarrhea, and dementia. A fourth “D,” death, occurs if pellagra is left untreated. In the skin, a thick, scaly, darkly pigmented rash develops symmetrically in areas exposed to sunlight. In fact, the word “pellagra” comes from “pelle agra,” the Italian phrase for rough skin. Symptoms related to the digestive system include inflammation of the mouth and tongue (“bright red tongue”), vomiting, constipation, abdominal pain, and ultimately, diarrhea. Gastrointestinal disorders and diarrhea contribute to the ongoing malnourishment of the patients. Neurologic symptoms include headache, apathy, fatigue, depression, disorientation, and memory loss and are more consistent with delirium than with the historically described dementia. Disease presentations vary in appearance since the classic triad rarely presents in its entirety. The absence of dermatitis, for example, is known as pellagra sine pellagra.

Reference: http://lpi.oregonstate.edu/mic/vitamins/niacin

Why do we need Niacin or Nicotinic acid?

One of the most important reasons why we all need niacin is that all of the B vitamins help to turn our food into energy. Niacin, in particular, helps increase “good” cholesterol and lower “bad” cholesterol. Niacin can also help to balance sex hormones.

Niacin is a direct precursor of coenzyme I and coenzyme II and plays an important role in animal and human energy utilization and the synthesis and breakdown of fats, proteins and carbohydrates.

Nicotinic acid is essential for normal function of the nervous system and the maintenance of healthy skin and mucous membranes. Without it, the body cannot convert food into glucose to produce energy.

Niacin or Nicotinic acid effect on triglycerides

Vitamin B3, better known as niacin, is also an effective at lowering triglycerides. Triglycerides are risk factors for cardiovascular disease. Serum triglyceride levels are affected by age, sex, and diet. Increased serum triglycerides can be seen in familial hypertriglyceridemia, eating large amounts of triglycerides and secondary to certain diseases such as diabetes, hypothyroidism, nephrotic syndrome and pancreatitis, atherosclerosis, and glycogen storage. Accumulation and other diseases.

The benefits of niacin on triglyceride levels are related to the vitamin’s effects on the liver. Niacin actually reduces the VLDL and LDL producing abilities of the organ. VLDL cholesterol is comprised primarily of triglycerides, which is why the benefits of niacin are so valuable for this purpose.

Does Niacin or Nicotinic acid lower blood pressure?

Nicotinic acid (niacin) is a well-established treatment for dyslipidaemia – an important cardiovascular disease (CVD) risk factor. However, niacin may also reduce blood pressure (BP), which is another important CVD risk factor.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705821/

Niacin or Nicotinic acid skin benefits

speed up cell metabolism and cell turnover (a process that slows down with age), revealing younger skin. It also helps heal wounds, repair sun damage and hyperpigmentation, and strengthen the skin barrier, making skin better able to retain moisture.

Niacin is also known to have a beneficial effect on skin cancer. Studies have shown that it can prevent premalignant cells from becoming malignant. And talking about anti-aging, niacin does play its part. One study showed that topical niacinamide helped reduce fine lines and wrinkles and other issues with skin elasticity concerned with aging.

How does Niacin or Nicotinic acid reduce cholesterol

niacin in very large doses can improve cholesterol levels and reduce the risk of heart attacks. In fact, when niacin’s beneficial effect was discovered in 1955, it became the first treatment for high cholesterol.

The main goal of cholesterol treatment is to lower bad cholesterol. niacin has the advantage of raising good cholesterol. It also lowers triglycerides, fats in the blood that can increase the risk of heart disease.

Is Niacin or Nicotinic acid good for weight loss

As niacin can break down fat and get rid of toxins stored in fat cells, so some hold the opinion it can help weight loss.

Niacin or Nicotinic acid use

Niacin or Nicotinic acid is used in dietary supplementation and also used to improve cardiovascular health and maintain healthy cholesterol levels. Today, many types of food (rice, cereals, milk, etc.) are enriched with Vitamin B3. Many breakfast drinks, soft and sport drinks contain a cocktail of vitamins. Niacin or Nicotinic acid is used in these formulations to cover approximately one third to one half of the daily requirement. Dietetic food include infant formulas, slimming diets, special foods for athletes, medical feeding ingredients (enteral nutrition products). In general, foods for special dietetic use are fortified with all essential vitamins, minerals and trace elements to prevent deficiencies. Niacin or Nicotinic acid is very stable as a pure substance, in vitamin premixes and in processes such as baking. It is an essential vitamin needed for protein, carbohydrate and fat metabolism.

Uses and Applications in Human Nutrition

Food and Beverage Fortification

Flour enrichment
Grain enrichment
Cereal enrichment
Energy drinks
Meal replacements

Health and Beauty Products

Cosmetics and toiletries
Anti-aging and acne skin care
Hair care
Face and body moisturizers
Toothpaste

Therapeutic Nutritional Ingredient

Infant formulas
Dietary supplements
Multivitamins
Nutritional beverages
Adult nutrition

Uses and Applications in Animal Nutrition

Vitamin B3 is essential to health of animal nutrition. Supplementation with vitamin B3 as niacin (nicotinic acid) or niacinamide (nicotinamide) helps animals metabolize feed to increase nutrient absorption and conversion to energy. As a leading manufacturer and supplier of the vitamin B3 and a leading supplier of vitamin B3 nutrition products for animal, human, and pharmaceutical applications. We have much extensive experience in the science of vitamin B3 supplementation into animal feed.

Feed Grade Niacin or Nicotinic acid: The amount and bioavailability of vitamins in animal feed is generally insufficient to fully nourish livestock. Therefore, supplementing with vitamin B3 Niacin or Nicotinic acid is essential. Deficiencies in vitamin B3 can be devastating to animals, resulting in decreased feed intake, retarded growth, weakness, and digestive tract disorders. In poultry the symptoms of malnutrition can include poor feathering, perosis, and black tongue.

Niacin-deficient pigs may develop ulcerative necrotic lesions in the gastro-intestinal tract, resulting in diarrhea and bacterial infection. Providing monogastric livestock with added vitamin B3Niacin or Nicotinic acid protects and promotes health of mucous membranes, central nervous system, skin, bones and joints. The following examples support the use of vitamin B3 supplementation for animal nutrition.

Animal Health: In ruminants, increased levels of vitamin B3 improve digestive tract health.
Growth and Feed Efficiency: Pigs fed with dietary vitamin B3 show increased gain-to-feed and pork quality; Vitamin B3 supplementation in chickens improves weight gain and feed utilization. Performance: In early-lactating dairy cows, dietary Niacin increases milk production via increased amounts of coenzymes NAD and NADP.

Why is Niacin or Nicotinic acid used in food?

Niacin and niacinamide are forms of Vitamin B3. Vitamin B3 is found in many foods including yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains.Niacin and niacinamide are also found in many vitamin B complex supplements with other B vitamins. Niacin is used for high cholesterol.

Niacin or Nicotinic acid food source

Niacin is found in a variety of foods. There are many Paleo friendly foods which contain this B vitamin, especially in great abundance. The top 4 foods, in fact, are all Paleo mainstays: tuna, chicken, pork and liver. Beef, mushrooms and avocado all contain niacin as well. In fact, it is a good idea to try and obtain all of your niacin via food. As you will see, it becomes harder to supplement with this vitamin than one would think.

Recommended Dietary Dosage of Niacin and Niacinamide

	Age, year	Weight, kg	Niacin, mg/d
Infants	0-0.5	6	5
Infants	0.5-1	9	6
Children	1-3	13	9
Children	4-6	20	12
Men	11-14	45	17
	15-18	66	20
	19-24	72	19
	25-50	79	19
	> 51	77	15
Women	11-14	46	15
	15-18	55	15
	19-24	58	15
	25-50	63	15
	> 51	65	13
Pregnant women			17
Nursing mothers			20

Examples:
Today, many types of food (rice, cereals, milk, etc.) are enriched with vitamins. Many breakfast drinks, soft and sport drinks contain a cocktail of vitamins. Niacin and Niacinamide are used in these formulations to cover approximately one third to one half of the daily requirement.

Dietetic food like infant formulas, slimming diets, special foods for athletes, medical feeding ingredients (enteral nutrition products). In general, foods for special dietetic use are fortified with all essential vitamins, minerals and trace elements to prevent deficiencies.

A classic example of food fortification is the addition of B vitamins (including niacin/niacinamide) to wheat flour.

Flour Enrichment
Application of specific premixes will result in a flour which meets the requirements of the respective authorities.

Required	mg per kg flour
	minimum	maximum
Vitamin B1	4.0	5.0
Vitamin B2	2.4	3.0
Niacin/Niacinamide	32.0	40.0
Iron (II)	26.0	33.0

Breakfast Drink

	content in 100 g
Niacinamide	18 mg
Vitamin B1	1.4 mg
Vitamin B2	1.6 mg
Vitamin B6	2 mg
Pantothenic acid	6 mg
Vitamin B12	1 microgram
Vitamin C	60 mg
Folic acid	0.2 mg
Biotin	0.15 mg
Vitamin A	0.8 mg
Vitamin D	5 microgram
Vitamin E	10 mg
Vitamin K	0.1 mg

Multivitamin Tablets
To ensure nutritional equivalence or to compensate for naturally occurring variations in nutrient levels or to compensate for a higher demand, multivitamin tablets with varying formulations are offered by the industry.

Typical Formulation of 1 Tablet (2.0g)

Vitamin	active content per tablet	% RDA
Niacinamide	0.9 mg	50 %
Vitamin C	30.0 mg	50 %
Pantothenic acid (Ca salt)	3.0 mg	50 %
Vitamin B1	0.7 mg	50 %
Vitamin B2	0.8 mg	50 %
Vitamin B6	1.0 mg	50 %
Vitamin B12	0.5 microgram	50 %
Folic acid	0.1 mg	50 %
Biotin	0.075 mg	50 %
Vitamin E	5.0 mg	50 %

Is Niacin or Nicotinic acid bad for you?

Commonly Niacin or Nicotinic acid is a considered safe vitamin, but there are several side effects that is bad for your health. The common side effects are as follows:

Nausea or vomiting
Diarrhea: niacin may cause diarrhea
Skin reactions, rashes
Headaches
Dizziness
Allergic reactions: Niacin supplements can cause allergies because some contain histamines, chemicals substances that can trigger allergic symptoms to be released
Heart problems: High doses of niacin may increase the risk of irregular heartbeats
Diabetes: Niacin and niacinamide might increase blood sugar. People with diabetes who take niacin or niacinamide should check their blood sugar carefully.
Worsened gallbladder or liver disease symptoms
Aggravated gout symptoms.
Low blood pressure
Stomach or intestinal ulcers
Problems after surgery controlling blood sugar levels

Reference: https://draxe.com/niacin-side-effects/

Niacin or Nicotinic acid Market

Vitamin B3 is one of the eight B-complex vitamins and plays an essential role in many physiological functions. The body constantly uses vitamin B3 to support metabolism of carbohydrates and proteins, blood circulation, and the functioning of the nervous system. Most people do not consume or synthesize enough dietary vitamin B3 to support adequate health wellness. A chronic lack of vitamin B3 can cause pellagra, a vitamin deficiency disease.

Over the years, Niacin has remained well-recognized for treating individuals with high cholesterols. In countries with malnutrition being one of the major concerns, regulatory bodies are setting up guidelines for food fortification including edible oil, salt, milk, wheat flour, and rice. The use of niacin and niacinamide in majority of these food products is one of the aspects of food fortification in these countries, in order to prevent vitamin B3 deficiency.

Deficiency of vitamin B3 leads to development of pellagra. Although pellagra is less prevalent in developed regions on the back of food fortification programs, certain countries in Africa such as Ethiopia, Zaire, and Malawi have a slew of reported cases related to pellagra.

A health-conscious trend is fostering across the developed regions, with consumer awareness concerning health benefits of various dietary supplements such as niacin and niacinamide witnessing a rise. In addition, utilization if niacin in the cosmetics, particularly in skin care cosmetics, is gaining huge attraction owing to its ability of protecting skin cells from UV rays.

As projected by Future Market Insights (FMI) in its new research analysis, the global market for niacin and niacinamide will ride on a steady CAGR during the forecast period (2017-2026). Global sales of niacin & niacinamide are estimated to garner roughly US$ 1,500 Mn revenues by 2026-end.

Reference: https://www.prnewswire.com/news-releases/niacin-and-niacinamide-market-global-industry-analysis-2012—2016–opportunity-assessment-2017—2026-300598863.html

Niacin or Nicotinic acid /Nicotinamide Price trend

Vitamin B3 Niacin or Nicotinamide is involved in lipid metabolism in the body, the process of tissue respiration and the anaerobic decomposition of carbohydrates. It is mainly used in the field of feed additives (67%), medical cosmetics (20%) and food (13%).

Supply side: Vitamin B3 is highly competitive and oversupply. In 2015, global production of niacinamide/nicotinic acid was about 65,000 tons, global demand was about 58,000 tons, and China’s demand was about 11199 tons. In 2015, China produced 21,700 tons, exported 11,600 tons, imported 2,000 tons, domestic supply totaled 12,100 tons and consumed 11,100 tons.

In 2016, the global output was about 24,900 tons, the export was 11,500 tons, the import was 1200 tons, the domestic supply totaled about 14,600 tons, and the total domestic demand was about 11,600 tons. In the past two years, the nicotinamide/nicotinic acid market has been fiercely competitive.

Price: The limited use of Paraquat inhibited VB3 intermediate product output, and the increase in intermediate prices has driven VB3 prices to rise.

The intermediate product of vitamin B3 is pyridine and 3-picoline as concomitant products. Pyridine is mainly used for the production of paraquat. Since 2012, the country has begun to restrict or prohibit paraquat. The national regulations of 2016 will stop the sale and use of paraquat aqueous solution in China since the 1st of July 2016. R & D of paraquat alternative formulations Bottleneck, there are no more new dosage forms in the country through the review, still only two types of formulations “pass”, the development of paraquat alternative formulations is very difficult. Upstream pyridine production is therefore limited, resulting in a decline in 3-methylpyridine production and an increase in the cost of vitamin B3. At the end of September 2016, the price of niacinamide began to rise from the bottom of 25 yuan/kg, and was recently maintained at 77.5 yuan/kg.

Niacin or Nicotinic acid Specification

Feed grade, assay ≥99.0%

Food grade, assay ≥99.5%

Recommended Niacin or Nicotinic acid dosage in livestock and aquatic animals

Recommended dosage in the formula of feed for Poultry & livestock & aquatic compound feed recommended amount:20-100g per ton.
Recommended dosage in the formula feed for cow during pregnancy and lactation period recommended amount:300g per ton

Packaging & Storage

Packaging: 25kg/carton or bag.
Storage: Store in dry, cool and dark places.
Shelf life: 24 months. Once the original cartons have been opened, please use the goods within a short period.

Niacin or Nicotinic acid manufacturers

Vitamin B3 Niacin or Nicotinic acid is an essential vitamin needed for protein, carbohydrate and fat metabolism.Niacin or Nicotinic acid is vitamin of the Vitamin-B group, the precursor in the synthesis of the pyridine coenzymes NAD and NADP involved in cell metabolism. Vitamin B3 can be found in various foods, but its bioavailability depends greatly on the source. China production occupies the large part in the world.

China is the big food and feed grade Niacin or Nicotinic acid manufacturers and export country in the world.

There are several Niacin or Nicotinic acid manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Niacin or Nicotinic acid manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Niacin or Nicotinic acid Samples are available if you need it for further test.

Where to buy Niacin or Nicotinic acid?

You can buy food or feed grade Niacin or Nicotinic acid from us. We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 20 May 2018
By Marketing
In Blog Article

Vitamin K3 Menadione Nicotinamide Bisulfite (MNB)

What is Menadione Nicotinamide Bisulfite?

Vitamin K3, MNB, Menadione Nicotinamide Bisulfite, it is a stabilized form of Vitamin K3 and it is more stable than another form of Vitamin K3 Menadione Sodium Bisulfite (MSB).

Appearance: white or ivory white crystalline powder

Menadione Nicotinamide Bisulfite Solubility: slightly soluble in water

Menadione Nicotinamide Bisulfite Molecular Formula: C17H16N2O6S

Molecular Weight: M=376.42

Chemical structure:

Function and the role of Vitamin K3 Menadione Nicotinamide Bisulfite in blood clotting

Vitamin k3 MNB Menadione Nicotinamide Bisulfite is essential for the life of animals, which takes the role in the synthesis of hepatic prothrombin in the liver, takes a unique hemostatic effect and simultaneously prevents the animals from the weakness and subcutaneous hemorrhage.

Vitamin k3 MNB Menadione Nicotinamide Bisulfite can reduce the bleeding and accelerate the recovery of wound and promote wrinkled chicken growth before or after beak breaking. It can relieve or even avoid the toxicity reaction when taking with Sulfa Drugs; It can also enhance diseases prevention by taking with anti-coccidian drug, white diarrhea and fowl cholera. With stress factors, the use of Menadione Sodium Bisulfite can relieve or even remove the stressful condition of animals while improving the effect of feeding.

MNB Menadione Nicotinamide Bisulfite Specification

MNB96: content of menadione ≥43.7%, content of nicotinamide≥31.2%

Recommended Menadione Nicotinamide Bisulfite dosage in livestock and aquatic animals

Recommended dosage in the formula of feed for livestock: MNB96: 2.5-11g per ton of compound feed.

Recommended dosage in the formula feed for aquatic animals: MNB96: 4.5-37g per ton of compound feed.

Packaging & Storage

Packaging: 25kg/carton net, inner plastic bag.
Storage: Store in dry, cool and dark places.
Shelf life: 12 months. Once the original cartons have been opened, please use the goods within a short period.

Menadione Nicotinamide Bisulfite Market

Menadione Nicotinamide Bisulfite manufacturers

The main role of Vitamin K3 Menadione Nicotinamide Bisulfite is to promote the formation of prothrombin, accelerate coagulation, maintain normal clotting time, and is an indispensable nutritional additive for animal growth and development. China production occupies the absolute leading position in the world.

China is the big Menadione Nicotinamide Bisulfite MNB manufacturers and export country in the world.

There are several Menadione Nicotinamide Bisulfite MNB manufacturers in China and abroad, as you know, the price of China suppliers can be better than abroad manufacturers. We have worked with China top manufacturer for years, we would like to recommend our selected Menadione Nicotinamide Bisulfite MNB manufacturers to you if you would like to save your purchasing cost with the same quality compared with abroad manufacturers. Menadione Nicotinamide Bisulfite Samples are available if you need it for further test.

Where to buy Menadione Nicotinamide Bisulfite?

You can buy Vitamin K3 Menadione Nicotinamide Bisulfite from us. We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

If you have any other questions, please email us through: info@foodsweeteners.com

Posted on 18 May 2018
By Marketing
In Blog Article

Sodium Saccharin E954

Saccharin and Sodium Saccharin E954

Saccharin

Sodium Saccharin E954

Dehydrate

Anhydrous

Application & Use

In low-calorie and sugar-free food & beverage

Sweeteners blends

In toothpaste?

In the feed?

Benefits

Zero glycemic index and beneficial to diabetes

Zero calories

Tooth health

Heat Stable

Safety

Safety supported

Side Effects

Sodium Saccharin VS Aspartame

Market Trend

Manufacturers

Manufacturing process

Vitamin C (L-Ascorbic acid)

What Is L-Ascorbic Acid?

Chemical Structure

Food Sources

D and L Types

L-Ascorbic acid

D-Ascorbic acid

Property

Manufacturing process

What Are Health Benefits To Our Body?

What Are Uses In Our Daily Life?

Food

Feed

Cosmetic

What Are The Possible Side effects?

Allergy symptoms

Market

Market demand will increase

Food and feed grade Vitamin B12 cyanocobalamin

What Is Vitamin B12 Cyanocobalamin?

Four types of Vitamin B12

1. Cyanocobalamin

2. Hydroxocobalamin

3. Methylcobalamin

4. Adenosylcobalamin

Property

Appearance

Stability

Solubility

Molar mass

Chemical Formula

Chemical Structure

What Are Food & Feed Uses Of Cyanocobalamin?

Food

Feed Additives/Poultry

What Are Possible Side effects?

Two FAQs

1. Does Cyanocobalamin Contain Cyanide?

Nature Sources Of Cyanide

2. What Is The Difference Between Methylcobalamin And Cyanocobalamin?

Specification

Feed Grade

Food Grade

How to choose best suitable Steviol glycosides for your production?

Steviol glycosides market trend

Steviol glycosides tastes misunderstanding

Generations of Steviol glycosides

First generation TSG series: recommended TSG95/RebA60

Second generation stevia monosaccharide, recommended RebA 97%~99%

Third generation: high purity steviol glycoside combination

Fourth generation: Glucosyl Stevia

Folic Acid Vitamin B9

What is Folic Acid?

Property

Another name for folic acid

Is folic acid a B vitamin?

Types of folic acid Vitamin B9

What Is Vitamin B₁₂Cyanocobalamin?

Four types of Vitamin B₁₂