Possible Side Effects of D-Biotin

Although D-Biotin generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

1. Acne. Getting too much biotin in your system increases your risk of developing cystic acne on the chin and jawline. The reason why this occurs is unknown, but it is found that the acne fades a few weeks after you stop using biotin supplements. Make sure you take doses of biotin that are less than 2500 mcg or less each day and drink plenty of water while using biotin supplements to reduce your risk of developing cystic acne. You may need to experiment with different doses until you find the amount that works best with your skin.
2. Allergies. Allergic reactions to biotin are not common, but they are still possible. People that have known allergies to vitamin B12 cobalamin or cobalt tend to be allergic to biotin as well. If you are suffering from an allergic reaction to biotin you may feel nausea, develop an itchy rash, tightness or pain in your chest and swelling of the throat and face. If you start to develop these symptoms call your doctor for help immediately as some of these developments can be fatal.
3. Miscarriage. If you are taking high doses of biotin while you are trying to get pregnant it can increase your risk of suffering a miscarriage. The reasoning behind this is not clear, and no tests have been performed on humans to better determine the likelihood of this risk. Talk to a medical professional before taking biotin while pregnant to ensure your safety.
4. Interactions. Biotin negatively interacts with anti-seizure medications and medications that help lower cholesterol, causing these medications to work less effectively. While biotin is helpful in regulating your metabolism and blood sugar levels, it can have a distinct effect on the overall blood glucose level in your body. If you are taking medications like cholesterol medication or anticonvulsants or treating a condition like diabetes, taking biotin can have an impact on your symptoms. It is rare that people have a life-threatening experience while taking biotin. There is only one recorded case where a woman that suffered from heart and lung condition known as eosinophilic pleuropericardial effusion developed life threatening conditions while taking vitamins B5 and B7 at high doses. After she stopped using these supplements her symptoms stopped. It is currently not known what role each of these vitamins or the combination of the two had in her symptoms.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Biotin is considered safe.

Suggested Dosage

• Infants 0 – 12 months: 7 micrograms per day (mcg/day)
• 1 to 3 years old: 8 mcg/day
• 4 to 8 years old: 12 mcg/day
• 9 to 13 years old: 20 mcg/day
• 14 to 18 years old: 25 mcg/day
• 18 and over, pregnant women: 30 mcg/day
• Breastfeeding women: 35 mcg/day

Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to D-Biotin populations. Better consult to your doctor if you would like to intake D-Biotin.